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Merck
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重要文件

I138

Sigma-Aldrich

1,5-Isoquinolinediol

≥98% (HPLC), powder

同義詞:

1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ

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About This Item

經驗公式(希爾表示法):
C9H7NO2
CAS號碼:
分子量::
161.16
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

mp

279-281  °C

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

Oc1cccc2c(O)nccc12

InChI

1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)

InChI 密鑰

LFUJIPVWTMGYDG-UHFFFAOYSA-N

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生化/生理作用

DiQ is a potent inhibitor of Poly(ADP-ribose) synthetase which is activated by nitric oxide; neuroprotective agent.

注意

Light sensitive

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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T Ruscetti et al.
The Journal of biological chemistry, 273(23), 14461-14467 (1998-06-11)
The DNA-dependent protein kinase (DNA-PK) is a heterotrimeric enzyme that binds to double-stranded DNA and is required for the rejoining of double-stranded DNA breaks in mammalian cells. It has been proposed that DNA-PK functions in this DNA repair pathway by
G M Wray et al.
Shock (Augusta, Ga.), 10(1), 13-19 (1998-08-04)
The nuclear enzyme poly(ADP-ribose) synthetase (PARS) is activated by DNA strand breakage, caused, for example by nitric oxide (NO), peroxynitrite, or oxygen-derived free radicals. Activation of PARS can cause intracellular energy depletion and cell death in vitro and may play
G M Shah et al.
Biochimica et biophysica acta, 1312(1), 1-7 (1996-06-05)
Activation of the poly(ADP-ribose) polymerase after oxidative damage is implicated in different responses of the cells, for example, cell recovery after sublethal damage or cell death after lethal damage. However, the extent and mechanism of involvement of the enzyme in
J C Docherty et al.
British journal of pharmacology, 127(6), 1518-1524 (1999-08-24)
The cardioprotective properties of inhibition of poly (ADP-ribose) synthetase (PARS) were investigated in the isolated perfused heart of the rat. Hearts were perfused in the Langendorff mode and subjected to 23 min total global ischaemia and reperfused for 60 min.
J A Walisser et al.
Experimental cell research, 251(2), 401-413 (1999-09-02)
Endothelial cells (EC) are subject to oxidative-induced cell death. Activation of poly(ADP-ribose) polymerase (PARP) occurs early in oxidant-induced EC injury and putatively mediates cell death by depleting its substrate, NAD(+). In this study, the role of PARP in H(2)O(2)-induced EC

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