推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 40 kDa
物種活性
human, mouse
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using heat retrieved, human intestine tissue
western blot (chemiluminescent): 5-10 μg/mL using mouse brain extract
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ELAVL4(1996)
mouse ... Elavl4(15572)
一般說明
Hu antigen D (HuD) protein is highly conserved and a neuron-specific RNA-binding protein. This protein belongs to the embryonic lethal, abnormal vision, Drosophila-like (ELAVL)/Hu family. The HuD gene is located on the human chromosome at 1p33-p32.3.
特異性
Anti-HuD specifically recognizes human and mouse HuD.
免疫原
synthetic peptide corresponding to amino acids 240-255 of human HuD with an N-terminal added cysteine, conjugated to KLH.
應用
Anti-HuD antibody produced in rabbit may be used in immunoblotting and immunohistochemistry.
生化／生理作用
Hu antigen D (HuD) protein binds to the 3′ untranslated region (UTR) of mRNA of genes like N-myc gene and growth-associated protein (GAP43). This binding results in an increase in the half-life of these mRNA. HuD plays a vital role in several regulatory processes, such as the processing of pre-mRNA, mRNA stability and translation. This protein is also involved in neuronal functioning and development. HuD protein also plays a role in neuronal plasticity, which includes, learning and memory, recovery from axonal injury and multiple neurological diseases.
標靶描述
HuD protein binds to the 3′ UTR of mRNA of geneslike N-myc gene and GAP43, and increases the half-life ofthese mRNA.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide and 1% inactivated bovine serum albumin.
儲存和穩定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
The Chromosomal Aberrations in the Head and Neck Squamous Cell Carcinoma Cell Lines: PCI-1, PCI-13 and PCI-50
Moon Y E, et al.
Korean Journal of Otorhinolaryngology - Head and Neck Surgery, 52(9), 741-750 (2009)
Lucas M Bronicki et al.
RNA (New York, N.Y.), 19(8), 1019-1037 (2013-07-19)
Precise control of messenger RNA (mRNA) processing and abundance are increasingly being recognized as critical for proper spatiotemporal gene expression, particularly in neurons. These regulatory events are governed by a large number of trans-acting factors found in neurons, most notably
Feifei Wang et al.
Anticancer research, 37(8), 4515-4522 (2017-07-26)
The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) cells and over 50% of neuroblastoma cells. The aim of this study was to investigate the serum HuD concentration in SCLC patients and
Riccardo De Santis et al.
Cell reports, 27(13), 3818-3831 (2019-06-27)
Amyotrophic lateral sclerosis (ALS) has been genetically linked to mutations in RNA-binding proteins (RBPs), including FUS. Here, we report the RNA interactome of wild-type and mutant FUS in human motor neurons (MNs). This analysis identified a number of RNA targets.
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