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A9511

Sigma-Aldrich

白蛋白 来源于人类血清

lyophilized powder, ≥97% (agarose gel electrophoresis)

同義詞:

HSA

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About This Item

CAS號碼:
70024-90-7
EC號碼:
274-272-6
MDL號碼:
MFCD00081418
分類程式碼代碼:
12352202
eCl@ss:
42010201
NACRES:
NA.25
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生物源

human

化驗

≥97% (agarose gel electrophoresis)

形狀

lyophilized powder

分子量

monomer calculated mol wt 66478 Da

技術

ELISA: suitable
tissue culture: suitable
western blot: suitable

雜質

HIV I and HIVII, HCV and HBsAg, tested negative

溶解度

H2O: soluble 50 mg/mL

UniProt登錄號

P02768

儲存溫度

2-8°C

SMILES 字串

FC(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI 密鑰

QYSGYZVSCZSLHT-UHFFFAOYSA-N

基因資訊

human ... ALB(213)

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相關類別

一般說明

人白蛋白的分子量为67 kDa。[1]
白蛋白是血浆中最丰富的蛋白质。肝脏可产生人白蛋白。 [2]

應用

与白蛋白结合的荧光已被用于慢性肾衰竭患者的血清中。[3]
来源于人血清的白蛋白已被用于：
  • 标准化分子排阻色谱柱[3]
  • 制备烟草花叶病毒（TMV）-聚乙二醇（PEG8）-血清白蛋白（SA）颗粒[4]
  • 在Fenton系统中分析其氧化后修饰[5]

生化／生理作用

白蛋白是可发现于动物的体液和组织及部分植物的种子中的一类可溶性单体蛋白。 血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白。 血清白蛋白在调节血液的胶体渗透压方面也是至关重要的。
白蛋白转换可见于患有缺铁性贫血的婴儿。[6]血清白蛋白是肝病的可靠预后指标。在晚期肝病中可见白蛋白的氧化修饰。[7]
血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白，对调节血液的胶体渗透压至关重要。研究还发现白蛋白可结合外源物质，特别是药物（例如布洛芬、华法林），并强烈影响其药代动力学。导致白蛋白氧化还原状态变化的氧化应激对其生理功能具有广泛的影响。

準備報告

使用Cohn, E.J., et al., J. Am. Chem. Soc., 69, 1753 (1947)中报道的方法IV进行制备。

其他說明

更多信息参见人血清白蛋白。

免責聲明

仅供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves

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分析證明 (COA)

Lot/Batch Number
0000433275
0000433275
0000429883
0000429882
0000429882

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Effects of Fenton Reaction on Human Serum Albumin: An In Vitro Study
Khosravifarsani M, et al.
Electron Physician, 8(9), 2970-2970 (2016)
Serum albumin camouflage of plant virus based nanoparticles prevents their antibody recognition and enhances pharmacokinetics
Pitek A, et al.
Biomaterials, 89(7-8), 89-97 (2016)
Elham Behzadi et al.
International journal of nanomedicine, 14, 257-270 (2019-01-16)
Recently, nanomaterials have moved into biological and medicinal implementations like cancer therapy. Therefore, before clinical trials, their binding to plasma proteins like human serum albumin (HSA) and their cytotoxic effects against normal and cancer cell lines should be addressed. Herein
H A Schwertner et al.
Clinical chemistry, 26(5), 649-652 (1980-04-01)
A band that is strongly fluorescent and migrates electrophoretically with serum albumin is commonly found in electrophoretograms of sera from patients with chronic renal failure. We sought to determine whether the fluorescence originates from binding of certain still-unidentified metabolites or
Daniele Sanna et al.
Inorganic chemistry, 49(1), 174-187 (2009-12-02)
The possible biotransformations in the blood serum of four representative insulin-enhancing vanadium compounds, [VO(6-mepic)(2)], cis-[VO(pic)(2)(H(2)O)], [VO(acac)(2)], and [VO(dhp)(2)], where 6-mepic, pic, acac, and dhp indicate the deprotonated forms of 6-methylpicolinic and picolinic acids, acetylacetone, and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone, were examined. In particular
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文章

Albumin in Cell Culture

Explore serum albumin's role in serum-free cell culture systems for biomanufacturing.

細胞培養中的白蛋白

探索血清白蛋白在生物製造的無血清細胞培養系統中的作用。

Questions

1–4 of 4 Questions  

  1. アルブミンの屈折率 情報ありますか？

    1 answer

    1. This product is not tested for refractive index, however, the incremental refractive index is reported in the general Human Serum Albumin datasheet.

      See page 2, PHYSICAL PROPERTIES, at the link below:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/175/446/a9511pis.pdf

      Helpful?

  2. Can Product A9511, Human serum albumin (HSA), be used for cell culture applications?

    1 answer

    1. Although A9511 is not sterile or endotoxin tested, it can probably still be used in cell culture. Filtering a solution of HSA through a 0.45 micron filter, then a 0.2 micron filter would provide a solution that is sterile, and likely suitable for cells. A5843 is an HSA product that has been endotoxin tested.

      Helpful?

  3. What are the impurities for Product A9511, Human serum albumin (HSA)?

    1 answer

    1. The impurities present are alpha-globulin and beta-globulin.

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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