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文件

C4024

Sigma-Aldrich

卡马西平

≥98% (HPLC), powder, antiepileptic agent

同義詞:

5H-二苯并[b,f]氮杂-5-甲酰胺

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About This Item

經驗公式（希爾表示法）:
C15H12N2O
CAS號碼:
298-46-4
分子量：:
236.27
EC號碼:
206-062-7
MDL號碼:
MFCD00005073
分類程式碼代碼:
12352200
eCl@ss:
34051404
PubChem物質ID:
57654002
NACRES:
NA.77

product name

卡马西平, powder

形狀

powder

mp

191-192 °C (lit.)

溶解度

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL
H2O: insoluble
ethanol: soluble
propylene glycol: soluble

起源

Novartis

儲存溫度

2-8°C

SMILES 字串

NC(=O)N1c2ccccc2C=Cc3ccccc13

InChI

1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

InChI 密鑰

FFGPTBGBLSHEPO-UHFFFAOYSA-N

基因資訊

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , PRNP(5621) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
rat ... Scn2a1(24766) , Scnn1a(25122) , Scnn1g(24768) , Slc6a1(79212)

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應用

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration. It has also been used to find out its effects on spontaneous seizures in rats.

生化／生理作用

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.
抗惊厥药；GABAA受体苯二氮卓调节位点的配体。钠离子通道抑制剂。

特點和優勢

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

分析證明 (COA)

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存取文件庫

Effect of antiepileptic drugs on spontaneous seizures in epileptic rats
Nissinen J and Pitkanen A
Epilepsy Research, 73(2), 181-191 (2007)
Role of carbamazepine in reducing polypharmacy in epilepsy
Maheshwari MC and Padmini R
Acta Neurologica Scandinavica, 64(1), 22-28 (1981)
Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of carbamazepine in wastewater treatment and during groundwater infiltration
Clara M, et al.
Water Research, 38(4), 947-954 (2004)
J P Johnson et al.
eLife, 11 (2022-03-03)
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (GoF) mutations lead to excess NaV1.6 sodium current, or other
Opeyemi Samson Osuntokun et al.
Toxicology reports, 7, 1592-1596 (2020-12-12)
This study investigated the effects of co-administration of carbamazepine (CBZ) with grape (Vitis vinifera) seed methanolic extract (GSME) on liver toxicity. Thirty-five male rats (145-155 g) were randomized into 5 groups (n = 7) and administered with propylene glycol (PG
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