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Merck
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重要文件

G4796

Sigma-Aldrich

京尼平

≥98% (HPLC), powder, insulin stimulator

同義詞:

(1S,2R,6S)-2-羟基-9-(羟甲基)-3-氧杂二环[4.3.0]壬-4,8-二烯-5-羧酸甲酯

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About This Item

經驗公式(希爾表示法):
C11H14O5
CAS號碼:
分子量::
226.23
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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產品名稱

京尼平, ≥98% (HPLC), powder

品質等級

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMSO: ≥25 mg/mL
H2O: insoluble

SMILES 字串

COC(=O)C1=CO[C@@H](O)C2C1CC=C2CO

InChI

1S/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3/t7-,9-,11-/m1/s1

InChI 密鑰

AZKVWQKMDGGDSV-BCMRRPTOSA-N

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一般說明

京尼平是一种天然的交联剂,从栀子果实中提取。[1]它可以防止脂质过氧化和一氧化氮的产生。京尼平保护海马神经元免受阿尔茨海默氏症淀粉样β蛋白的毒性。它具有抗炎和抗血管生成的作用。[2]京尼平参与药物输送系统。[3]

應用

京尼平已被用于:
  • 化学敏感性测定[4]
  • 制备重组人(rh)- 多基因成釉细胞相关蛋白(ODAM)- 浸渍胶原凝胶和体外矿化试验[5]
  • 京尼平凝胶制剂[6][7]

生化/生理作用

京尼平以 UCP2 依赖性方式刺激胰岛素分泌(解偶联蛋白 2)。 京尼平是蛋白质、胶原蛋白、明胶和壳聚糖交联剂。

特點和優勢

该化合物在受体分类和信号转导手册的 InsR 页面上有重点介绍。如需浏览其他手册页面,请点击此处

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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分析證明 (COA)

Lot/Batch Number

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Effect of inorganic salts and glucose additives on dose-response, melting point and mass density of genipin gel dosimeters
Al-Jarrah AM, et al.
Physica Medica : PM : An International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB), 32(1), 36-41 (2016)
Jong-Hwa Kim et al.
Scientific reports, 10(1), 15836-15836 (2020-09-29)
Rotavirus is the leading cause of acute gastroenteritis among young children worldwide. However, agents specifically designed to treat rotavirus infection have not been developed yet. In this study, the anti-rotavirus and anti-inflammatory effects of genipin, a chemical compound found in
Implications of protein-and peptide-based nanoparticles as potential vehicles for anticancer drugs
Elzoghby AO, et al.
Advances in Protein Chemistry and Structural Biology, 98, 169-221 (2015)
The enamel protein ODAM promotes mineralization in a collagen matrix
Ikeda Y, et al.
Connective tissue research, 59(sup1), 62-66 (2018)
Costantino Del Gaudio et al.
Biomaterials, 34(31), 7754-7765 (2013-07-19)
Rapid and controlled vascularization of engineered tissues remains one of the key limitations in tissue engineering applications. This study investigates the possible use of natural extracellular matrix-like scaffolds made of gelatin loaded with human vascular endothelial growth factor (VEGF), as

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