推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~125 kDa
物種活性
human
包裝
antibody small pack of 25 μL
濃度
~1.0 mg/mL
技術
western blot: 2-4 μg/mL using K562 cell lysates
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... XPO1(7514)
mouse ... Xpo1(103573)
rat ... Xpo1(85252)
一般說明
Exportin 1/Crm1 (also known as XPO1, Exp1, chromosome region maintenance 1 protein homolog) is mapped to human chromosome 2p15.
應用
Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
生化／生理作用
Exportin 1/Crm1 has been implicated in various steps during mitosis.
Exportin-1 is a protein encoded by the XPO1 gene in humans. It is a novel cell-cycle regulated gene that is essential for the nuclear export signal-dependent nuclear export of proteins. XPO1 is highly expressed in mantle cell lymphoma (MCL) cells. It acts as selective inhibitor of nuclear export (SINE) compounds that induce apoptosis in MCL cells. XPO1 is expressed in subpopulation of Gastric cancer (GC) with aggressive behavior and can serve as a prognosis marker for poor outcome. It has helical hairpin HEAT repeats and a C-terminal helical extension (C-extension). The C-extension helps in regulating CRM1′s cargo-binding affinity by modulating the conformation and flexibility of its HEAT repeats.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Effects of exportin 1 on nuclear transport and meiotic resumption in porcine full-grown and growing oocytes
Onuma A, et al.
Biology of Reproduction, 98(4), 501-509 (2017)
Cyril Dian et al.
Structure (London, England : 1993), 21(8), 1338-1349 (2013-07-16)
Chromosome region maintenance 1/exportin1/Xpo1 (CRM1) associates with the GTPase Ran to mediate the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 consists of helical hairpin HEAT repeats and a C-terminal helical extension (C-extension) that inhibits the
Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma.
Yoshimura M, Ishizawa J, Ruvolo V, et al.
Cancer Science, 105(7), 795-801 (2014)
Clinical and molecular characteristics of XPO1 mutations in patients with chronic lymphocytic leukemia
Jain P, et al.
American Journal of Hematology, 91(11), E478-E478 (2016)
CRM1-mediated nuclear export: to the pore and beyond
Hutten S, et al.
Trends in Cell Biology, 193-201 (2007)
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