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重要文件

D7128

Sigma-Aldrich

L-二氢乳清酸

≥99%

同義詞:

2,6-二氧六氢-4-嘧啶羧酸, L-氢乳清酸, 二氢-L-乳清酸

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About This Item

經驗公式(希爾表示法):
C5H6N2O4
CAS號碼:
分子量::
158.11
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.83
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化驗

≥99%

形狀

powder

mp

254-255 °C (dec.) (lit.)

SMILES 字串

OC(=O)[C@@H]1CC(=O)NC(=O)N1

InChI

1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1

InChI 密鑰

UFIVEPVSAGBUSI-REOHCLBHSA-N

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應用

L-二氢乳清酸(DHO)用作二氢乳清酸脱氢酶(DHODH)检测的底物。[1][2][3]

生化/生理作用

L-二氢乳清酸(DHO)是二氢乳清酸脱氢酶(DHODH)的底物,而DHODH是一种从头合成嘧啶的酶。抑制剂对DHOH的抑制作用会导致上游代谢物DHO大量积累和尿苷水平下降。因此,DHO和尿苷可作为嘧啶合成的生物标志物,用于临床开发DHOH抑制剂。[4]

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Feng Yin et al.
Journal of pharmaceutical and biomedical analysis, 192, 113669-113669 (2020-10-30)
Uridine and L-dihydroorotate (DHO) are important intermediates of de novo as well as salvage pathways for the biosynthesis of pyrimidines, which are the building blocks of nucleic acids - DNA and RNA. These metabolites are known to be significant biomarkers
Yihan Wu et al.
Cell chemical biology, 24(12), 1437-1444 (2017-10-17)
Microbial natural products are genetically encoded by dedicated biosynthetic gene clusters (BGCs). A given BGC usually produces a family of related compounds that share a core but contain variable substituents. Though common, the reasons underlying this divergent biosynthesis are in
Mihwa Lee et al.
Journal of molecular biology, 348(3), 523-533 (2005-04-14)
Escherichia coli dihydroorotase has been crystallized in the presence of the product, L-dihydroorotate (L-DHO), and the structure refined at 1.9A resolution. The structure confirms that previously reported (PDB entry 1J79), crystallized in the presence of the substrate N-carbamyl-D,L-aspartate (D, L-CA-asp)
Laura Martorano et al.
Disease models & mechanisms, 12(3) (2019-03-06)
Mitochondrial DNA depletion syndromes (MDS) are a group of rare autosomal recessive disorders with early onset and no cure available. MDS are caused by mutations in nuclear genes involved in mitochondrial DNA (mtDNA) maintenance, and characterized by both a strong
O Björnberg et al.
Archives of biochemistry and biophysics, 391(2), 286-294 (2001-07-05)
The flavoprotein dihydroorotate dehydrogenase (DHOD) catalyzes the oxidation of dihydroorotate to orotate. Dihydrooxonate is an analogue of dihydroorotate in which the C5 carbon is substituted by a nitrogen atom. We have investigated dihydrooxonate as a substrate of three DHODs, each

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