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C9756

Sigma-Aldrich

胆钙化醇

≥98% (HPLC)

同義詞:

(+)-维生素 D3, 活化7-脱氢胆固醇, 活化7-脱氢胆甾醇, 胆骨化醇

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About This Item

經驗公式（希爾表示法）:
C27H44O
CAS號碼:
67-97-0
分子量：:
384.64
Beilstein:
2339331
EC號碼:
200-673-2
MDL號碼:
MFCD00078131
分類程式碼代碼:
12352209
eCl@ss:
34058003
PubChem物質ID:
24893192
NACRES:
NA.26
暫時無法取得訂價和供貨情況

生物源

synthetic (organic)

化驗

≥98% (HPLC)

形狀

powder

技術

HPLC: suitable

顏色

white to off-white

mp

83-86 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

InChI 密鑰

QYSXJUFSXHHAJI-YRZJJWOYSA-N

基因資訊

human ... VDR(7421)

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相關類別

一般說明

胆钙化醇作为一种激素前体，因为它需要两个代谢阶段：首先是 25-羟胆钙化醇；然后加入 1α，25-二羟胆钙化醇。一个单位（U.S.P. 或国际）定义为 USP 维生素 D 参考标准中含有 0.025 μg 维生素D3 的活性。
胆钙化醇来源于饮食或皮肤接触紫外线。口服维生素 D3 容易被吸收，并储存在脂肪组织中。[1]

應用


  • 早期肾功能损害的老年人中肾-骨轴调节因子、炎症和铁状态的改变以及维生素D补充的影响。：该研究旨在探讨胆骨化醇在老年肾功能损害患者肾骨轴、炎症反应和铁代谢中的重要作用。通过补充维生素D，研究人员观察到可以指导未来治疗策略的关键变化（Christodoulou M et al., 2024）。

  • 25-羟基维生素D3对多发性硬化症患者临床结局的影响一项随机、双盲临床试验——试点研究。：本临床试验评估胆钙化醇在改善多发性硬化症患者健康结局方面的疗效。使用胆钙化醇可能增强神经功能并减少疾病进展，说明其在神经退行性疾病管理中的重要作用（Maghbooli Z et al., 2024）。

  • 维生素D能够通过抑制NLRP3炎性体通路调节COVID-19相关严重程度。：这项关键研究通过对NLRP3炎症小体通路的调节作用，将胆钙化醇与降低COVID-19严重程度相关联。这些发现强调了维生素D作为一种调节剂在对抗病毒感染的免疫反应中的潜力（Khalil B et al., 2024）。

  • 维生素D补充对肥胖或超重个体中枢血流动力学参数和自主神经系统的影响。：这项随机对照试验探讨了胆钙化醇补充剂如何影响肥胖或超重患者的心血管和自主神经功能，为其在骨骼健康之外的益处和心血管调节作用提供了启示（Faria ACC et al., 2024）。


生化／生理作用

在慢性肾病中经常观察到维生素 D 的缺乏。[2]
维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。
维生素 D 通过调控正常细胞和癌细胞增殖和分化的受体而发挥作用。

儲存和穩定性

胆钙化醇 C9756 在氩气下包装。如果未开封储存在 2-8°C 且避光，则本产品可以稳定保存至少三年。未使用的部分应储存在氮气或氩气下。在冰箱温度下，在棕色-抽真空安瓿中储存一年后，变质可忽略不计。它会在几天内被潮湿的空气氧化和灭活。

相關產品

產品號碼
描述
訂價

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000406067
0000406065
0000402824
0000402825
0000390858

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Lin Fu et al.
Journal of immunology (Baltimore, Md. : 1950), 203(5), 1198-1207 (2019-07-19)
It is increasingly recognized that excessive glucocorticoids induce fetal intrauterine growth restriction (IUGR). Placental 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), a glucocorticoid-catalyzing enzyme, prevents active glucocorticoids from maternal circulation into the fetus, thus protecting against IUGR. Previous studies demonstrated gestational LPS exposure
Patricia Fernandez-Robredo et al.
Antioxidants (Basel, Switzerland), 9(9) (2020-09-12)
Diabetic retinopathy is a vision-threatening microvascular complication of diabetes and is one of the leading causes of blindness. Oxidative stress and inflammation play a major role in its pathogenesis, and new therapies counteracting these contributors could be of great interest.
Stefan Pilz et al.
Hypertension (Dallas, Tex. : 1979), 65(6), 1195-1201 (2015-03-25)
Vitamin D deficiency is a risk factor for arterial hypertension, but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). We aimed to evaluate whether vitamin D supplementation affects 24-hour systolic ambulatory BP monitoring values
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Questions

1–5 of 5 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Hi Please advise how to make retest for your products C9756-5G Regards

    1 answer

    1. Products are retested according to the schedule set by Quality guidelines. In the case of C9756, the retest occurs every 3 years. Retesting only occurs if ample stock is available of the specific lot. Product retesting is not performed if the batch has sold out, nor is retesting performed upon request. Should stock remain, retesting will be performed near the assigned retest date. Should the lot continue to meet all specifications, the lot retest date is extended and an updated Certificate of Analysis will be generated.

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  4. Dear Sirs, could you please advise the CRM for your product C9756 Lot.No. SLCK8275 and advise the associated uncertainty . Regards

    1 answer

    1. Product PHR1237 is offered as a Certified Reference Material. The product C9756 is not a Certified Reference Material nor is it tested against a CRM. It is intended for research use only. Items that are Certified Reference Materials will be clearly stated as such in the product title as well as the in the "Properties" section.

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  5. I am a professor and researcher from an university in Turkey. We bought your C9756 product for cell culture use. How can we resolve and dilute the product (C9756) for cell culture? Thanks for your help

    1 answer

    1. This material has not been tested in a cell culture application. However, the material can be dissolved in 50 mg/ml of ethanol as mentioned on the Certificate of Analysis.

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