C9774

胆钙化醇

analytical standard

• 同義詞: (+)-维生素 D₃, 活化7-脱氢胆固醇, 活化7-脱氢胆甾醇, 胆骨化醇
• 經驗公式（希爾表示法）: C₂₇H₄₄O
• CAS號碼: 67-97-0
• 分子量：: 384.64
• Beilstein: 2339331
• EC號碼: 200-673-2
• MDL號碼: MFCD00078131
• 分類程式碼代碼: 12352205
• eCl@ss: 34058003
• PubChem物質ID: 24893197
• NACRES: NA.77

屬性

• 生物源: synthetic (organic - wool)
• 品質等級: 200
• 等級: analytical standard
• 化驗: ≥97.0%
• 形狀: crystalline
• 包裝: pkg of 250 mg
• 顏色: white
• mp: 83-86 °C (lit.)
• 儲存溫度: 2-8°C
• SMILES 字串: CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
• InChI: 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
• InChI 密鑰: QYSXJUFSXHHAJI-YRZJJWOYSA-N
• 基因資訊: human ... VDR(7421)

描述

一般說明

Cholecalciferol, also called vitamin D₃, promotes the absorption of calcium and phosphorus in the body to regulate bone growth. It is most commonly found in humans and animals and is produced in our skin when exposed to sunlight. It is used to treat and prevent bone disorders (such as rickets, osteomalacia).[1][2]

應用

Cholecalciferol has been used as an internal standard in high-performance liquid chromatography (HPLC) to analyze serum vitamin D levels.[3][4] It has also been used as a standard in liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to quantify vitamin D3 in sunflower oil.[5]

Cholecalciferol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.[6]

生化／生理作用

维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。

维生素 D 通过调控正常细胞和癌细胞增殖和分化的受体而发挥作用。

Cholecalciferol is sourced either through the diet or exposing skin to ultraviolet rays. Oral administration of vitamin D3 is readily absorbed and is stored in adipose tissue.[7] Deficiency of vitamin D is often observed in chronic kidney disease.[8]

包裝

Packaged in flame-sealed ampules under Argon

安全資訊

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300 + H310 + H330,H372
• 防範說明: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• 危險分類: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges