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Merck
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重要文件

C9393

Sigma-Aldrich

氯唑西林 钠盐 一水合物

β-lactamase-resistant antibiotic

同義詞:

Cloxacillin, Sodium cloxacillin monohydrate

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About This Item

線性公式:
C19H17ClN3O5SNa · H2O
CAS號碼:
分子量::
475.88
EC號碼:
MDL號碼:
分類程式碼代碼:
51102829
PubChem物質ID:
NACRES:
NA.85
暫時無法取得訂價和供貨情況

形狀

powder or crystals

抗生素活性譜

Gram-positive bacteria

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

O.[Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O

InChI

1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

InChI 密鑰

KCUWTKOTPIUBRI-VICXVTCVSA-M

一般說明

Chemical structure: ß-lactam

應用

Cloxacillin is effective against infections caused by penicillin G-resistant staphylococci.[1] It was used in studies of topical antibacterial agents for burn and crush wounds.[2]

生化/生理作用

Cloxacillin is a semi-synthetic antibiotic and a chlorinated derivative of oxacillin. It inhibits the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cloxacillin is often used as AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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分析證明 (COA)

Lot/Batch Number

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A New Antibacterial Agent: Sodium Cloxacillin Monohydrate (Tegopen)
Journal of the American Medical Association, 195, 569-570 (1966)
Methenamine salts as topical antibacterial agent. I. Experimental studies for burn and crush wound.
T Matsumoto et al.
Archives of surgery (Chicago, Ill. : 1960), 101(1), 71-77 (1970-07-01)
Anna Stefánsdóttir et al.
Acta orthopaedica, 84(1), 87-91 (2013-02-16)
Prosthetic joint infections can be caused by bacteria derived from the patient's skin. The aim of the study was: (1) to determine which bacteria colonize the nose and groin in patients planned for primary hip or knee arthroplasty, (2) to
Atypical presentation of joint infection by an unusual organism.
S P Roy et al.
Journal of postgraduate medicine, 57(4), 338-339 (2011-11-29)
Ai Lee Lim et al.
The Medical journal of Malaysia, 67(3), 340-341 (2012-10-23)
Lemierre syndrome is an uncommon disease which commonly arise from acute bacterial oropharyngeal infection. This disease was first described in 1900 by Courmont and Cade Lemierre. It is commonly caused by Fusobacterium necrophorum. Lemierre syndrome has been reported to be

Questions

  1. In cosa può essere solubilizzata e a quale concentrazione massima?

    1 answer
    1. This material is soluble in water at 50 mg/mL.

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