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Merck
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重要文件

27555

Sigma-Aldrich

氯唑西林 钠盐

≥95.0% (HPLC)

同義詞:

3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt, Syntarpen sodium salt

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About This Item

經驗公式(希爾表示法):
C19H17ClN3NaO5S
CAS號碼:
分子量::
457.86
Beilstein:
4103180
EC號碼:
MDL號碼:
分類程式碼代碼:
51102829
PubChem物質ID:
NACRES:
NA.85
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生物源

semisynthetic

化驗

≥95.0% (HPLC)

形狀

powder or crystals

雜質

≤5% Total impurities (anhydrous)

顏色

white to off-white

抗生素活性譜

Gram-positive bacteria

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

[Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O

InChI

1S/C19H18ClN3O5S.Na/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);/q;+1/p-1/t13-,14+,17-;/m1./s1

InChI 密鑰

SCLZRKVZRBKZCR-SLINCCQESA-M

一般說明

Chemical structure: ß-lactam

應用

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness[1] and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria[2].

生化/生理作用

Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Sandrine Lemaire et al.
Antimicrobial agents and chemotherapy, 51(5), 1627-1632 (2007-02-20)
Early studies showed that methicillin-resistant Staphylococcus aureus (MRSA) strains are susceptible to beta-lactams when they are exposed to pH < or = 5.5 in broth. Because S. aureus survives in the phagolysosomes of macrophages, where the pH may be acidic
Farahnaz Pahlavanzadeh et al.
The Yale journal of biology and medicine, 93(1), 29-34 (2020-04-01)
Today, resistance to antibacterial agents is the most important problem facing public health. Pseudomonas aeruginosa is a common gram-negative bacterium and an important cause of nosocomial infections. Resistance to many antibiotics in strains of P. aeruginosa isolated from hospital settings
E Kheadr et al.
Antimicrobial agents and chemotherapy, 51(1), 169-174 (2006-10-25)
The effects of acid, oxgall, and H(2)O(2) on susceptibilities to antibiotics and nisin were examined for 13 strains of bifidobacteria. Susceptibilities to ampicillin, cloxacillin, penicillin, vancomycin, kanamycin, neomycin, paramomycin, streptomycin, chloramphenicol, erythromycin, tetracycline, and nisin A were assayed by a
M Britzi et al.
Journal of veterinary pharmacology and therapeutics, 37(5), 445-450 (2014-03-29)
The pharmacokinetics of ampicillin in dogs was determined after intravenous (i.v.) bolus and constant rate infusion. Ampicillin was administered to six beagle dogs as an i.v. bolus at 20 mg/kg and as a constant rate i.v. infusion (CRI) at 20 mg/kg during

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