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重要文件

C9026

Sigma-Aldrich

雨蛙素

≥95% (HPLC), suitable for immunohistochemistry

同義詞:

[Tyr(SO3H)4]雨蛙素, pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2, 硫酸化蓝肽, 蓝肽, 雨蛙肽

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About This Item

經驗公式(希爾表示法):
C58H73N13O21S2
CAS號碼:
分子量::
1352.40
Beilstein:
5422487
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26
暫時無法取得訂價和供貨情況

產品名稱

雨蛙素, ≥95% (HPLC)

品質等級

化驗

≥95% (HPLC)

形狀

powder

技術

immunohistochemistry: suitable

顏色

white

儲存溫度

−20°C

SMILES 字串

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(NC(=O)[C@H](Cc3ccc(OS(O)(=O)=O)cc3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]4CCC(=O)N4)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc5ccccc5)C(N)=O

InChI

1S/C58H73N13O21S2/c1-29(72)49(71-57(87)40(23-31-12-14-33(15-13-31)92-94(89,90)91)68-56(86)43(26-48(78)79)69-52(82)37(16-18-44(59)73)65-51(81)36-17-19-45(74)63-36)58(88)62-28-46(75)64-41(24-32-27-61-35-11-7-6-10-34(32)35)54(84)66-38(20-21-93-2)53(83)70-42(25-47(76)77)55(85)67-39(50(60)80)22-30-8-4-3-5-9-30/h3-15,27,29,36-43,49,61,72H,16-26,28H2,1-2H3,(H2,59,73)(H2,60,80)(H,62,88)(H,63,74)(H,64,75)(H,65,81)(H,66,84)(H,67,85)(H,68,86)(H,69,82)(H,70,83)(H,71,87)(H,76,77)(H,78,79)(H,89,90,91)/t29-,36+,37+,38+,39+,40+,41+,42+,43+,49?/m1/s1

InChI 密鑰

YRALAIOMGQZKOW-HJMGKOKZSA-N

尋找類似的產品? 前往 產品比較指南

Amino Acid Sequence

Glp-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

應用

蛙皮素可用于诱导Sprague-Dawley大鼠、小鼠和其他实验动物产生胰腺炎。[1][2][3]

生化/生理作用

对疼痛感知的影响是相互矛盾的。它可以预防胆囊疼痛、肾绞痛和间歇性跛行疼痛;然而,一般来说,它是内源性阿片类药物的拮抗剂。
蛙皮素是一种胃调节分子,其作用类似于胆囊收缩素。[4]它有一个硫酸酪氨酸残基,可诱导平滑肌收缩。它具有胃泌素样活性。[5]蛙皮素可用于研究由NF-κB上调细胞间黏附分子1(ICAM-1)和炎症相关分子(如NADPH氧化酶和Janus激酶信号转导蛋白)等蛋白介导的细胞信号传导。[6]蛙皮素还调控体温调节、镇静和饱腹感。[5]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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存取文件庫

Acinar cell apoptosis and the origin of tubular complexes in caerulein-induced pancreatitis
Lynne E Reid
International Journal of Experimental Pathology (1999)
Abba Kastin, Abba J. Kastin
Handbook of Biologically Active Peptides (2011)
Membrane Proteome Analysis of Cerulein-Stimulated Pancreatic Acinar Cells: Implication for Early Event of Acute Pancreatitis
Jangwon Lee
Gut and Liver, 4(1) (2010)
Shan-Ming Chen et al.
Scientific reports, 10(1), 20319-20319 (2020-11-25)
Pancreatic cancer is one of the most lethal and chemo-resistant cancers worldwide. Growing evidence supports the theory that the gut microbiota plays an essential role in modulating the host response to anti-cancer therapy. The present study aimed to explore the
Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia
Gastroenterology, 999-1010 (2016)

Questions

1–5 of 5 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. How do I store solutions of Product C9026, Caerulein?

    1 answer
    1. Solutions can be frozen at pH>7 for a least a week, and may be good for several months.

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  4. What is Product C9026, Caerulein, soluble in?

    1 answer
    1. It is soluble in 50 mM ammonium hydroxide at a concentration of 1 mg/mL. Note that this is information from analytical testing, and is not application based.

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  5. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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