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L4391

Sigma-Aldrich

脂多糖 来源于大肠杆菌 0111:B4

Lipopolysaccharides from Escherichia coli O111:B4

γ-irradiated, BioXtra, suitable for cell culture

同義詞:

LPS

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About This Item

CAS號碼:
93572-42-0
EC號碼:
297-473-0
MDL號碼:
MFCD00164401
分類程式碼代碼:
12352211
NACRES:
NA.75
暫時無法取得訂價和供貨情況

生物源

Escherichia coli (O111:B4)

品質等級

300

無菌

γ-irradiated

產品線

BioXtra

形狀

lyophilized powder

純化經由

gel-filtration chromatography

儲存條件

desiccated

技術

cell based assay: suitable
cell culture | mammalian: suitable

雜質

<1% Protein (Lowry)

溶解度

H2O: 5 mg/mL, slightly hazy

應用

clinical research
life science and biopharma

儲存溫度

2-8°C

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相關類別

一般說明

脂多糖 (LPS) 是由脂质和多糖组成的复杂分子，主要存在于革兰氏阴性菌的外膜中。LPS 由脂质 A、核心低聚糖 (core) 和 O 特异性多糖或 O 抗原 (Oag) 组成，固定在细菌外膜上，脂质 A 主要负责其相关毒性。作为促炎反应的有效激活剂，LPS 参与多种哺乳动物细胞，包括巨噬细胞、单核细胞和内皮细胞。在保护革兰氏阴性菌免受环境胁迫的同时，LPS 也在感染过程中触发先天免疫系统的识别。

應用

脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。
该LPS血清型已用于刺激B细胞并在人肝细胞中诱导NOS。

生化／生理作用

脂多糖是绝大多数革兰氏阴性菌细胞壁的一种主要组成成分。它是一种高免疫原性抗原，具有增强针对可溶性抗原免疫应答的能力。LPS还可作为来自小鼠、兔、鸡、牛、仓鼠和人骨髓来源的B淋巴细胞的一种特异性促分裂原。

特點和優勢

  • 高纯度化合物适用于各种研究应用

重構

脂多糖以经γ-射线处理的冻干粉形式提供。如需重悬，可将1 ml无菌的平衡盐溶液或组织培养基加入至小瓶（1 mg）中并轻轻晃动直至粉末溶解。重悬后的产品可采用无菌的平衡盐溶液或组织培养基进一步被稀释至所需的工作浓度。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品，建议您访问我们的碳水化合物分类页面。
如需了解生化试剂系列的更多信息，请填写此表。

相關產品

產品號碼
描述
訂價

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
0000297998
0000252542
0000185317
0000187965
059M4173V

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Chuan Yan et al.
Journal of hepatology, 63(2), 420-428 (2015-04-02)
Chronic inflammation is a major etiological factor for hepatocellular carcinoma (HCC), but how immune cells respond in the initiation of hepatocarcinogenesis remains uncharacterized. This study aims to investigate the response and roles of neutrophils in early hepatocarcinogenesis. By inducible expression
Kelly L Brown et al.
Journal of immunology (Baltimore, Md. : 1950), 186(9), 5497-5505 (2011-03-29)
The human cathelicidin peptide, LL-37, is a host defense peptide with a wide range of immunomodulatory activities and modest direct antimicrobial properties. LL-37 can exert both pro- and anti-inflammatory effects and can modulate the proinflammatory responses of human peripheral blood
Christopher R Shaler et al.
PLoS biology, 15(6), e2001930-e2001930 (2017-06-21)
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome
Jennifer Vandooren et al.
Haematologica, 102(10), 1671-1682 (2017-08-05)
Lipopolysaccharides or endotoxins elicit an excessive host inflammatory response and lead to life-threatening conditions such as endotoxemia and septic shock. Lipopolysaccharides trigger mobilization and stimulation of leukocytes and exaggerated production of pro-inflammatory molecules including cytokines and proteolytic enzymes. Matrix metalloproteinase-9
Zhuoran Yin et al.
Neurobiology of aging, 55, 115-122 (2017-04-25)
Alzheimer's disease (AD) is strongly associated with microglia-induced neuroinflammation. Particularly, Aβ plaque-associated microglia take on an "activated" morphology. However, the function and phenotype of these Aβ plaque-associated microglia are not well understood. We show hyperreactivity of Aβ plaque-associated microglia upon
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文章

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

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