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Merck
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重要文件

E4389

Sigma-Aldrich

β-Estradiol-Water Soluble

BioReagent, suitable for cell culture

同義詞:

Cyclodextrin-encapsulated 17β-estradiol

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About This Item

MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

生物源

synthetic (organic)

無菌

non-sterile

產品線

BioReagent

形狀

powder

技術

cell culture | mammalian: suitable

溶解度

H2O: 25 mg/mL, clear to slightly hazy

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@H]2O.C[C@@H]5[C@@H](O)[C@@H]6O[C@H](CO)[C@H]5O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](O[C@H]9O[C@H](CO)[C@@H](O[C@H]%10O[C@H](CO)[C@@H](O[C@H]%11O[C@H](CO)[C@@H](O[C@H]%12O[C@H](CO)[C@@H](O6)[C@H](O)[C@H]%12O)[C@H](O)[C@H]%11O)[C@H](O)[C@H]%10O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8OCCCO)[C@H](O)[C@H]7O

InChI

1S/C46H78O35.C18H24O2/c1-12-20(55)40-68-13(5-48)32(12)75-41-26(61)25(60)37(18(10-53)69-41)81-46-39(67-4-2-3-47)31(66)38(19(11-54)74-46)80-45-30(65)24(59)36(17(9-52)73-45)79-44-29(64)23(58)35(16(8-51)72-44)78-43-28(63)22(57)34(15(7-50)71-43)77-42-27(62)21(56)33(76-40)14(6-49)70-42;1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h12-66H,2-11H2,1H3;3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-;14-,15-,16+,17+,18+/m11/s1

InChI 密鑰

XMURHKLFGRLVRW-JKDYGSMVSA-N

一般說明

β-estradiol is a natural human estrogen. It is vital for the growth of breast and reproductive epithelia, maturation of long bones and development of secondary sexual characteristics.[1] Estradiol is produced by immature germ cells, spermatozoa, Leydig cells and Sertoli cells.[2] β-estradiol acts as a menopausal hormones. It is involved in replacement therapy for female hypogonadism or primary ovarian failure. Reduced levels of β-estradiol are linked to heart disease and osteoporosis.[1] Estradiol plays a critical role in proliferation, modulation of ion transport and control of apoptosis in Sertoli cells. It maintains sperm concentration, motility and morphology.[2]

應用

β-estradiol has been used:
  • to culture differentiated adipocytes[3]
  • for estradiol treatment in rats[4]
  • for oocyte maturation in vitro[5]
β-Estradiol is used to study cell differentiation and transformations (tumorigenicity). This product is not recommended for use in binding assays.

包裝

Package size based on estradiol

其他說明

Contains 40-55 mg estradiol per gram of solid; balance 2-hydroxypropyl-β-cyclodextrin.

象形圖

Health hazardEnvironment

訊號詞

Danger

危險分類

Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3


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分析證明 (COA)

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存取文件庫

Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia
Saraceno GE, et al.
Frontiers in Pharmacology, 9, 335-335 (2018)
Impact of l-carnitine on lipid content and post thaw survivability of buffalo embryos produced in vitro
Verma M, et al.
Cryobiology, 82(, 99-105 (2018)
Maria M Escribese et al.
Blood, 112(12), 4574-4584 (2008-09-20)
Dendritic cells (DCs) play a central role in initiating and polarizing the immune response. Therefore, DC maturation represents a key control point in the shift from innate to adaptive immunity. It is suspected that during pregnancy, hormones are critical factors
Keith T Akama et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(6), 2333-2339 (2003-03-27)
Estrogens induce synaptogenesis in the CA1 region of the dorsal hippocampus during the estrous cycle of the female rat. Functional consequences of such estrogen-mediated synaptogenesis include cyclic changes in neurotransmission and memory. At the molecular level, estrogen stimulates the rapid
Mathanraj Packiam et al.
Infection and immunity, 78(1), 433-440 (2009-11-11)
Acute gonorrhea in women is characterized by a mucopurulent exudate that contains polymorphonuclear leukocytes (PMNs) with intracellular gonococci. Asymptomatic infections are also common. Information on the innate response to Neisseria gonorrhoeae in women is limited to studies with cultured cells

Questions

1–4 of 4 Questions  
  1. what is the molecular weight of E-4389 product?

    1 answer
    1. This is a dual-component product. A single molecular weight does not apply. The molecular weight of the B-estradiol is 272.38 grams per mol, and the molecular weight of the 2-hydroxypropyl-β-cyclodextrin is 1396 grams per mol. The package size of 100 mg is in reference to the B-Estradiol. This product contains 40 - 50 mg per gram solid. The lot-specific B-estradiol content is reported in the Certificate of Analysis.

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  2. What is the storage stability of E4389, β-Estradiol - Water Soluble (25 mg/mL complex) in distilled water at 4C, -20C, or -80C?

    1 answer
    1. This product is stable for 6 months at -20°C in a non-defrosting freezer after solubilizing in distilled water. There is no stability data for this product at 4°C or -80°C.

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  3. How do I calculate the molarity of product E4389, β-Estradiol - Water Soluble?

    1 answer
    1. Product E4389 (β-Estradiol-Water Soluble) is a complex of β-Estradiol and cyclodextrin. Cyclodextrin is used to aid in the solubility of β-Estradiol into water. In order to prepare a molar solution of β-Estradiol you will have to base it on the β-Estradiol content in the solution and not the entire complex.

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  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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