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Merck
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重要文件

C5135

Sigma-Aldrich

蓖麻油，乙氧基化

pH range 6.0-8.0

同義詞:

Cremophor® EL, PEG-35蓖麻油, 乙氧基化蓖麻油, 聚甲醛-35蓖麻油

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About This Item

CAS號碼:
61791-12-6
MDL號碼:
MFCD00130879
分類程式碼代碼:
12161902
NACRES:
NA.25
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描述

non-ionic

品質等級

200

形狀

liquid

分子量

~2500 g/mol

pH值範圍

6.0-8.0

HLB

12 - 14

應用

sample preservation

SMILES 字串

ClCC(OC(=O)N)CCl

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI 密鑰

JMNCUXPHXKHBPY-UHFFFAOYSA-N

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相關類別

一般說明

乙氧基化蓖麻 油是一种非离子增溶剂和乳化剂，是环氧乙烷和蓖麻油反应生成的。它是一种浅黄色油状液体，在26°C以上澄清，气味不强但很特别。
乙氧基化蓖麻 油是聚环氧乙烷表面活性剂，具有粘性。它的亲水疏水平衡值为12-14。[1]

應用

乙氧基化蓖麻 油可用作洗涤剂，增强颜料溶解度和跨膜渗透性。[2][3]它可用作细胞内药物/激活剂递送的载体。[4][5]

生化／生理作用

乙氧基化蓖麻油用于脂质制剂药物和化妆品增溶。[1]乙氧基化蓖麻油适合生产含有水不溶性活性物质等疏水化合物的半固体和液体制剂。[1]由于具有乳化作用，它可用于基于生物膜的药物转运研究。[6]

其他說明

是蓖麻油和环氧乙烷的一种衍生物。

法律資訊

Cremophor is a registered trademark of BASF SE

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

494.6 °F - Not applicable

閃點（°C）

257 °C - Not applicable

個人防護裝備

Eyeshields, Gloves

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分析證明 (COA)

Lot/Batch Number
BCCL7415
BCCL7416
BCCM3065
BCCK9841
BCCJ9623

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Timek T
The Annals of Thoracic Surgery, 66, 1618-1618 (1998)
Colloidal nanocarriers for the enhanced cutaneous delivery of naftifine: characterization studies and in vitro and in vivo evaluations
Erdal MS, et al.
International journal of nanomedicine, 11, 1027-1027 (2016)
A nonionic polyethylene oxide (PEO) surfactant model: experimental and molecular dynamics studies of Kolliphor EL
Suys EJA, et al.
Journal of Pharmaceutical Sciences, 108(1), 193-204 (2019)
Large-scale imaging of cortical network activity with calcium indicators.
Ikegaya Y
Neuroscience Research, 52, 132-132 (2005)
M Batisse-Lignier et al.
Oncogene, 36(31), 4445-4456 (2017-04-04)
Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Pan-genomic analyses identified p53/Rb and WNT/β-catenin signaling pathways as main contributors to the disease. However, isolated β-catenin constitutive activation failed to induce malignant progression in mouse adrenocortical tumors. Therefore, there
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Questions

1–9 of 9 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Can this be stored in -20C?

    1 answer

    1. This product is to be stored at room temperature. Storing the product at freezer temperatures has not been evaluated and may cause degradation.

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  4. How much is the Cloud Point?

    1 answer

    1. The cloud point is not determined.

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  5. What is the hydrophile-lipophile balance (HLB) for Cremophor EL (Product No. C5135)?

    1 answer

    1. The manufacturer (BASF) reports an HLB value of between 12 and 14 for Cremophor EL (Product No. C5135).

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  6. What is the molecular weight of Cremophor EL (Product No. C5135)?

    1 answer

    1. The manufacturer (BASF) reports a molecular weight of approximately 2500 for Cremophor EL (Product No. C5135).

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  7. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  8. How can Cremophor EL (Product No. C5135) be sterilized?

    1 answer

    1. The manufacturer (BASF) recommends that it be sterilized by heating in an autoclave for 30 minutes at 120°C. It may acquire a somewhat deeper color. Either the neat material or neutral aqueous solutions may be autoclaved.

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  9. What solvents can I use to prepare a solution of Cremophor EL (Product No. C5135)? Or is it already in solution?

    1 answer

    1. Cremophor EL is a neat liquid, sold by weight. It is not already in solution. It is soluble in water; note that the solubility in water actually decreases with an increase in temperature. It is also soluble in many organic solvents, such as ethanol, isopropyl alcohol, chloroform and others.

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