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Merck
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重要文件

B9806

Sigma-Aldrich

肝素−生物素 钠盐

≥97%

同義詞:

肝素-生物素偶联物

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About This Item

MDL號碼:
MFCD03457057
分類程式碼代碼:
12352201
eCl@ss:
34058011
NACRES:
NA.25
暫時無法取得訂價和供貨情況

共軛

biotin conjugate

品質等級

200

化驗

≥97%

形狀

solid

分子量

~15000 Da

溶解度

H2O: soluble 1 mg/mL, clear, colorless

儲存溫度

2-8°C

相關類別

應用

肝素-生物素用于转染研究，用于开发自组装的三链体，例如聚酰胺基胺树枝状聚合物和DNA（PAMAM/DNA）肝素-生物素三链体，用于靶向基因转运，并改善转染。该三链体可用于固定蛋白质如乳铁蛋白和溶菌酶以及核酸。[1][2]

其他說明

猪肠粘膜肝素偶联的生物素

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
MKCT7646
MKCT6676
MKCS7114
MKCQ8048
MKCP6851

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存取文件庫

Kelly M Kitchens et al.
Advanced drug delivery reviews, 57(15), 2163-2176 (2005-11-18)
This article summarizes our efforts to evaluate the potential of poly (amidoamine) (PAMAM) dendrimers as carriers for oral drug delivery. Specifically, the permeability of a series of cationic PAMAM-NH2 (G0-G4) dendrimers across Caco-2 cell monolayers was evaluated as a function
Qiao Zhang et al.
Bioconjugate chemistry, 21(11), 2086-2092 (2010-10-12)
To improve transfection efficiency and to incorporate target ligands to the gene delivery systems, heparin and heparin-biotin were introduced to complexes of polyamidoamine dendrimer and DNA (PAMAM/DNA) via electrostatic interactions to form self-assembled PAMAM/DNA/heparin and PAMAM/DNA/heparin-biotin terplexes, respectively. The self-assembled
Nan Liu et al.
Die Pharmazie, 67(2), 174-181 (2012-04-20)
The efficiency and safety of gene delivery vectors were important factors for gene therapy. To enhance gene transfection efficiency and to incorporate biocompatible components to the polyamidoamine (PAMAM) dendrimer mediated gene delivery systems, human serum albumin (HSA) was introduced to
S Zou et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 103(4), 889-895 (1992-12-01)
1. Binding of biotin-heparin to immobilized lactoferrin and lysozyme was optimum at pH 6.0, 100 mM NaCl. Complex interactions between NaCl and CaCl2 concentrations were observed for heparin binding to both proteins. 2. The metal ions Cu2+, Zn2+, Fe2+ and
Xue-Qing Zhang et al.
Bioconjugate chemistry, 18(6), 2068-2076 (2007-09-13)
We report on the preparation and characterization of poly(D, L-lactide-co-glycolide) (PLGA) microparticles with surface-conjugated polyamidoamine (PAMAM) dendrimers of varying generations. The buffering capacity and zeta-potential of the PLGA PAMAM microparticles increased with increasing generation level of the PAMAM dendrimer conjugated.
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Questions

  1. Hello, is this product (B9806) a mixture of heparin lengths? How accurate is your estimation that it is 15000 daltons in size? How is this product made? Synthetically or by purification from an animal sample?

    1 answer

    1. The quality specification for product B9806 is that the molecular weight is approximately 15000 Daltons. This is only an approximation and no specific screening has been performed for other chain lengths. The source of the heparin is from porcine intestinal mucosa. The biotinylation method is considered proprietary.

      The following reference provides information on the biotinylation of heparin:
      Stearns, N., et al., Synthesis and Characterization of Highly Sensitive Heparin Probes for Detection of Heparin-Binding Proteins. Analytical Biochemistry, 247, 348 (1997).

      Helpful?

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