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重要文件

PHR1003

Supelco

阿司匹林

Pharmaceutical Secondary Standard; Certified Reference Material

同義詞:

乙酰水杨酸, 2-乙酰氧基苯甲酸, O-乙酰水杨酸, ASA, 阿司匹林

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1 G


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1 G

About This Item

線性公式:
2-(CH3CO2)C6H4CO2H
CAS號碼:
分子量::
180.16
Beilstein:
779271
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24


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等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to BP 617
traceable to Ph. Eur. A0200000
traceable to USP 1044006

API 家族

aspirin

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

mp

134-136 °C (lit.)

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-30°C

SMILES 字串

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChI 密鑰

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

基因資訊

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一般說明

阿司匹林(乙酰水杨酸)是一种环氧化酶抑制剂[1]和抗血小板剂,广泛应用于心脏病发作和中风的二级预防。[2]
用于质量控制应用的药物二级标准品为制药行业实验室及制造商内部工作标准品的制备提供了一种方便、高性价比的替代方案。

應用

这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
阿司匹林(乙酰水杨酸)可用作药物参考标准品,用于[2]通过分光光度技术[2]和反相高效液相色谱技术定量测定药物制剂中的分析物。[1]

生化/生理作用

通过抑制环加氧酶(前列腺素H合酶)阻断前列腺素的产生,其对COX-1同种型具有更高的选择性。抗血栓形成作用是由于血小板中COX-1的抑制阻断了血栓素的产生和血小板的聚集。化学预防结肠直肠和其他实体肿瘤。
通过抑制环氧化酶(前列腺素H合酶),对COX-1亚型具有更高的选择性,阻止前列腺素的产生。抗血栓作用是由于COX-1在血小板中的抑制作用,阻止血栓形成和血小板聚集。 对结直肠及其他实体肿瘤有化学预防作用。

分析報告

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他說明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

腳註

欲查看该材料的分析证书示例,请在下面的栏位中输入LRAB7669。这只是一个示例证书,可能不是您收到的批次。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

482.0 °F

閃點(°C)

250 °C


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Preliminary studies on the analgesic activity of latex of Calotropris procera
Dewan.S, et al.
Journal of Ethnopharmacology, 73, 307-311 (2000)
Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil
Shinde.AU, et al.
Journal of Ethnopharmacology, 65, 21-27 (1999)
Simultaneous determination of clopidogrel and aspirin in pharmaceutical dosage forms
Mishra P and Dolly A
Indian Journal of Pharmaceutical Sciences, 63(3) (2006)
Rapid and simultaneous determination of aspirin and dipyridamole in pharmaceutical formulations by reversed-phase high performance liquid chromatography (RP-HPLC) method
Prakash K, et al.
African Journal of Pharmacy and Pharmacology, 5(2), 244-251 (2011)
Andrew O Maree et al.
Journal of the American College of Cardiology, 46(7), 1258-1263 (2005-10-04)
We investigated whether use of low-dose enteric-coated (EC) aspirin for secondary prevention of cardiovascular events has sufficient bioavailability to achieve complete platelet cyclooxygenase (COX) inhibition in all individuals. Aspirin reduces cardiovascular morbidity and mortality in patients with pre-existing vascular disease;

Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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