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A1824

Sigma-Aldrich

N-乙酰-5-羟色胺

≥99% (HPLC), powder, antioxidant

同義詞:

N-乙酰羟色胺, N-乙酰羟色胺

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About This Item

經驗公式(希爾表示法):
C12H14N2O2
CAS號碼:
分子量::
218.25
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.32
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產品名稱

N-乙酰-5-羟色胺, ≥99% (HPLC), powder

品質等級

化驗

≥99% (HPLC)

形狀

powder

顏色

white to faint yellow

mp

120-122 °C (lit.)

溶解度

ethanol: 50 mg/mL

儲存溫度

2-8°C

SMILES 字串

CC(=O)NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)

InChI 密鑰

MVAWJSIDNICKHF-UHFFFAOYSA-N

基因資訊

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一般說明

N-乙酰血清素 (NAS)(又称normelatonin)是色氨酸代谢途径中褪黑激素的前体。[1]

應用

N-乙酰基-5-羟色胺已被用于治疗神经元细胞,并分析其对Krüppel样因子15(KLF15)表达的影响。[2]

生化/生理作用

N-乙酰血清素(NAS,又称normelatonin)可以保护神经元,因为它能够防止氧化胁迫。 它还可以抑制转录因子NF-κB的作用。[3]NAS具有抗氧化和抗衰老作用。它可以防止β-淀粉质引起的神经毒性。它有助于维持生物膜的最佳流动性能。[1]
褪黑激素的直接前体。它由血清素和乙酰辅酶 A 在血清素 N-乙酰转移酶(褪黑激素生物合成中的限速酶)催化下形成的。该吲哚胺是褪黑激素受体的弱激动剂,对 G 蛋白刺激和 cAMP 积累的抑制有一定的作用。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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N-acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-kappaB
Lezoualch F, et al.
Journal of Pineal Research, 24(3), 168-178 (1998)
Jimo Borjigin et al.
Molecular and cellular endocrinology, 349(1), 13-19 (2011-07-26)
The pineal gland is a neuroendocrine organ of the brain. Its main task is to synthesize and secrete melatonin, a nocturnal hormone with diverse physiological functions. This review will focus on the central and pineal mechanisms in generation of mammalian
Izabela Sadowska-Woda et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(3), 879-884 (2009-12-08)
beta-Cyfluthrin is one of the most widely used type II pyrethroid in agriculture. The aim of this study was to examine (1) the possibility of beta-cyfluthrin to induce oxidative stress in human erythrocytes in vitro and its effect on catalase
J K Yao et al.
Molecular psychiatry, 15(9), 938-953 (2009-04-30)
Schizophrenia is characterized by complex and dynamically interacting perturbations in multiple neurochemical systems. In the past, evidence for these alterations has been collected piecemeal, limiting our understanding of the interactions among relevant biological systems. Earlier, both hyper- and hyposerotonemia were
KLF15 regulates dopamine D2 receptor and participates in mouse models of neuropathic pain.
Junfei Z, et al.
Biochemical and Biophysical Research Communications, 492(2), 269-274 (2017)

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