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重要文件

H9523

Sigma-Aldrich

3-(2-氨乙酸)吲哚 盐酸盐

Serotonin hydrochloride
1 of 2 reviewers received a sample product or took part in a promotion

≥98%, powder, neurotransmitter

同義詞:

3-(2-氨基乙基)-5 -羟基吲哚 盐酸盐, 5-羟色胺, 5-羟色胺 盐酸盐

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About This Item

經驗公式(希爾表示法):
C10H12N2O · HCl
CAS號碼:
分子量::
212.68
Beilstein:
3570963
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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產品名稱

3-(2-氨乙酸)吲哚 盐酸盐, powder

化驗

≥98%

品質等級

形狀

powder

顏色

white to off-white

mp

149-154 °C (lit.)

溶解度

H2O: 17 mg/mL
0.1 M HCl: 22 mg/mL
ethanol: 5.3 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cl[H].NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

InChI 密鑰

MDIGAZPGKJFIAH-UHFFFAOYSA-N

基因資訊

human ... HTR3A(3359)

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一般說明

血清素普遍存在于所有动物中。它在中枢和外周神经系统中(CAN/PNS)发挥多样功能,是一种激素和丝裂原分子,[1]血清素由大脑中的轴突终末生产。[2]动作电位引发血清素释放,在突触中扩散结合到突触后受体引起神经反应。血清素在发育、呼吸、体温调节、内分泌、心血管和胃肠道功能中起重要作用。[2]还在睡眠觉醒周期、性、情绪、记忆、攻击性、痛觉、学习和认知等感知觉行为中发挥作用。[2]血清素影响多种精神障碍,包括精神分裂、神经性厌食症、抑郁,还影响强迫症、惊恐发作和社交恐惧症等焦虑障碍。血清素水平变化与药物滥用、赌博、注意力缺陷障碍、强迫症和冲动性的冲动相关障碍或人格障碍有关。[3]

應用

盐酸血清素用于:研究5-羟色胺受体拮抗剂调节肝脏球状体纤维化的机制[4],研究其对人胚胎肾脏细胞细胞外信号调节激酶(ERK)磷酸化的影响[5],用于结肠癌细胞系的transwell试验、愈伤试验和肿瘤同种异体移植试验[6]

生化/生理作用

神经递质。

特點和優勢

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面, 请单击此处

準備報告

溶液需新鲜配制。

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Repr. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

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已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Rhian Stavely et al.
Inflammatory bowel diseases, 24(5), 1021-1034 (2018-04-19)
Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious
L F Mohammad-Zadeh et al.
Journal of veterinary pharmacology and therapeutics, 31(3), 187-199 (2008-05-13)
5-Hydroxytryptamine, or serotonin, is a biogenic amine most noted for its role as a neurotransmitter. Manipulation of serotonin in animal models was used as a tool for studying its role in humans. Through such research serotonin has been shown to
Sara Redenšek Trampuž et al.
Scientific reports, 14(1), 1396-1396 (2024-01-17)
Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a
Serotonin Receptors
Nichols David E and Nichols Charles D.
Chemical Reviews (2008)
Soaleha Shams et al.
Behavioral neuroscience, 131(6), 492-504 (2017-12-01)
Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the

文章

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

血清素儲存在細胞中,並經 MAO 代謝,影響中樞神經系統、消化道和血小板功能。

Questions

1–8 of 8 Questions  
  1. Hello, what colour is the solution supposed to be when dissolved? Best, Anaïs

    1 answer
    1. When prepared in water at 100 mg/mL, this material is expected to be clear to very slightly hazy in solution. While there is no specification for the color,
      historical records indicate a range of faint yellow to light brown in solution.

      Helpful?

  2. Can it be stored -20C

    1 answer
    1. The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.

      Helpful?

  3. What is the purity of Product H9523, Serotonin hydrochloride?

    1 answer
    1. This product must be at least 98% pure according to our specifications.  The purity for individual lots can be found on the certificate of analysis.

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  5. Has Product H9523, Serotonin hydrochloride, been cell culture tested?

    1 answer
    1. No. We do not test this product for cell culture suitability.

      Helpful?

  6. What are the storage conditions for Product H9523, Serotonin hydrochloride?

    1 answer
    1. This product is a powder and should be refrigerated at 2-8°C. We do not recommend storing solutions of this product.

      Helpful?

  7. Can I store solutions of Product H9523, Serotonin hydrochloride?

    1 answer
    1. Solutions of this product are unstable.  We recommend preparing this solution fresh for each application.

      Helpful?

  8. Is Product H9523, Serotonin hydrochloride, the neurotransmitter serotonin?

    1 answer
    1. This product is the neurotransmitter serotonin.  Other synonyms for this product are 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, and 5-Hydroxytryptamine hydrochloride.

      Helpful?

Reviews

1 of 2 reviewers received a sample product or took part in a promotion

Active Filters

  1. Decatur, GA
    • Review 1
    • Votes 0
    4 out of 5 stars.

    good experience

    We had a mix-up with the shipping of this product, and the company was great to work with getting it sorted out

    Helpful?

  2. 1 Ratings-Only Review

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