跳轉至內容
Merck
全部照片(2)

文件

286583

Sigma-Aldrich

5-甲氧基色胺

97%

同義詞:

2-(5-甲氧基吲唑-3-基)乙胺, 3-(2-氨基乙基)-5-甲氧基吲哚, 5-MOT, 5-甲氧基吲哚-3-乙胺, NSC 56422, 去乙酰褪黑素

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C11H14N2O
CAS號碼:
分子量::
190.24
Beilstein:
145587
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

97%

形狀

solid

mp

121-123 °C (lit.)

SMILES 字串

COc1ccc2[nH]cc(CCN)c2c1

InChI

1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3

InChI 密鑰

JTEJPPKMYBDEMY-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

一般說明

5-甲氧色胺(一种褪黑素的代谢物)在人角质细胞中应对紫外B(UVB)的保护性作用已得到研究

應用

5-甲氧基色胺作为一种激动剂已被用于5-羟色胺1受体的药理作用研究中
用于制备以下物质的反应物:
  • shishijimicin A的咔啉二糖结构域
  • 褪黑激素类似物用于降低眼压
  • 5-HT4受体配体
  • 分选酶A和异柠檬酸裂解酶的抑制剂
  • 用于治疗缺血/再灌注(I/R)损伤的治疗剂
  • Aurora和表皮生长因子受体激酶抑制剂
  • 用于治疗人乳头瘤病毒感染的药剂
  • Manzamine类似物用于控制神经炎症和脑部感染
  • 促炎细胞因子的抑制剂
  • Tacrine-melatonin杂合物作为阿尔茨海默病的多功能药物

包裝

无底玻璃瓶。内含物在插入的融合锥体内。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Amir Hanna-Elias et al.
European journal of medicinal chemistry, 44(7), 2952-2959 (2009-02-19)
Twenty-three indole-3-methanamines were designed, synthesized and evaluated as ligands for the 5-HT(4) receptor. Compounds I-d, I-j, I-o, I-q and I-u showed good affinity at 100 microM and I-o was found to be only 5-fold less potent than the agonists serotonin
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.
Janjetovic Z, Nahmias ZP, Hanna S, et al.
Journal of Pineal Research, 57(1), 90-102 (2014)
Hyun-Ji Kim et al.
Combinatorial chemistry & high throughput screening, 11(4), 316-324 (2008-05-14)
Continuous identification and validation of novel drug targets require the development of rapid, reliable, and sensitive cell-based high-throughput screening (HTS) methods for proposed targets. Recently, the 5-HT(6) receptor (5-HT(6)R), a member of the class of recently discovered 5-HT receptors, has
Jeff DeFalco et al.
Bioorganic & medicinal chemistry letters, 20(23), 7076-7079 (2010-10-23)
5-Benzyloxytryptamine 19 was found to act as an antagonist of the TRPM8 ion-channel. For example, 19 had an IC(50) of 0.34 μM when menthol was used as the stimulating agonist. Related commercially-available tryptamine derivatives showed diminished, or no antagonist activity
John M Corkery et al.
Progress in neuro-psychopharmacology & biological psychiatry, 39(2), 259-262 (2012-06-12)
5-MeO-DALT (N,N-diallyl-5-methoxytryptamine) is a psychoactive substance, sold primarily over the Internet as a 'research chemical' or 'plant food'. Although details for the synthesis of this tryptamine have been available since 2004, its use as a hallucinogenic drug has been reported

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務