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重要文件

A0885

Sigma-Aldrich

金精三羧酸 铵盐

powder

同義詞:

ATA, 亚氨基三羧酸铵, 铝试剂

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About This Item

線性公式:
C22H14O9 · 3NH3
CAS號碼:
分子量::
473.43
顏色索引編號:
43810
Beilstein:
3900820
EC號碼:
MDL號碼:
分類程式碼代碼:
12171500
PubChem物質ID:
NACRES:
NA.47
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生物源

synthetic

形狀

powder

顏色

dark red

mp

220-225 °C (dec.) (lit.)

溶解度

water: soluble 100 mg/mL, dark red

λmax

552 nm (λmax: )

應用

diagnostic assay manufacturing
hematology
histology

儲存溫度

room temp

SMILES 字串

N.N.N.OC(=O)c1cc(ccc1O)\C(c2ccc(O)c(c2)C(O)=O)=C3/C=CC(=O)C(=C3)C(O)=O

InChI

1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31);3*1H3

InChI 密鑰

AIPNSHNRCQOTRI-UHFFFAOYSA-N

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應用

金精三羧酸铵盐已被用作核酸酶抑制剂来研究其对转染的影响。[1]

生化/生理作用

金精三羧酸易于在水溶液中聚合,形成稳定的自由基,抑制蛋白质-核酸相互作用。它通过阻止核酸与酶的结合而成为核糖核酸酶和拓扑异构酶 II 的有效抑制剂。它刺激酪氨酸磷酸化过程,包括 NB2 淋巴瘤细胞中的 Jak2/STAT5 途径,神经母细胞瘤细胞中的 ErbB4,以及 PC12 细胞中的 MAP 激酶、Shc 蛋白、磷脂酰肌醇 3-激酶和磷脂酶 C。金精三羧酸抑制许多细胞类型的细胞凋亡。其神经保护作用,可能是由于其能够阻止 Ca2+ 不可渗透的 GluR2 受体的下调或其抑制钙蛋白酶的能力,钙蛋白酶是一种在凋亡过程中被激活的 Ca2+ 激活的蛋白酶。

其他說明

可能含有大量的聚合物材料。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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