D9016

双氯西林 钠盐 一水合物

• 同義詞: 3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl penicillin sodium salt monohydrate
• 經驗公式（希爾表示法）: C₁₉H₁₆Cl₂N₃NaO₅S·H₂O
• CAS號碼: 13412-64-1
• 分子量：: 510.32
• EC號碼: 206-444-3
• MDL號碼: MFCD00167147
• 分類程式碼代碼: 51102829
• PubChem物質ID: 24894242
• NACRES: NA.85

屬性

• 形狀: powder or crystals
• 品質等級: 200
• 顏色: white to off-white
• 溶解度: H₂O: 100 mg/mL
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: cell wall synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: O.[Na+].Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C([O-])=O)-c4c(Cl)cccc4Cl
• InChI: 1S/C19H17Cl2N3O5S.Na.H2O/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
• InChI 密鑰: SIGZQNJITOWQEF-VICXVTCVSA-M

描述

一般說明

Chemical structure: ß-lactam

應用

Dicloxacillin is a β-lactamase resistant penicillin similar to oxacillin. Dicloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. It is resistant to penicillinase. It is used to study bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking and to study mechanisms of penicillinase (β-lactamase) resistance. It is used to study phenylbutazone plasma binding and extracellular and intracellular killing of Staphylococcus aureus

生化／生理作用

Docloxacillin binds to specific penicillin-binding proteins (PBPs) in the bacterial cell wall and therefore inhibits the last stage of bacterial cell wall synthesis. Cell lysis, mediated by bacterial cell wall autolytic enzymes, is the result. Dicloxacillin may interfere with autolysin inhibitors .

安全資訊

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H315,H319,H334,H335
• 防範說明: P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves