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N21804

Sigma-Aldrich

3-硝基苯肼 盐酸盐

98%

同義詞:

1-（3-硝基苯基）肼盐酸盐, 3-硝基苯肼单盐酸盐, 3-硝基苯肼盐酸盐, 间硝基苯肼盐酸盐

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About This Item

線性公式:
O2NC6H4NHNH2 · HCl
CAS號碼:
636-95-3
分子量：:
189.60
EC號碼:
211-270-6
MDL號碼:
MFCD00012939
分類程式碼代碼:
12352100
PubChem物質ID:
24897354
NACRES:
NA.22
暫時無法取得訂價和供貨情況

化驗

98%

形狀

powder

mp

210 °C (dec.) (lit.)

SMILES 字串

Cl.NNc1cccc(c1)[N+]([O-])=O

InChI

1S/C6H7N3O2.ClH/c7-8-5-2-1-3-6(4-5)9(10)11;/h1-4,8H,7H2;1H

InChI 密鑰

BKOYKMLGFFASBG-UHFFFAOYSA-N

相關類別

一般說明

3-Nitrophenylhydrazine (3-NPH) is a derivatizing reagent used for the derivatization of carboxyl- and carbonyl-containing metabolites. This compound is also used as a high-efficiency chemical isotope-labeling reagent. Additionally, 3-nitrophenylhydrazine undergoes a condensation reaction with substituted benzaldehydes resulting in the formation of a series of ten substituted (E)-1-benzylidene-2-(3-nitrophenyl) hydrazine compounds. [1] [2]

應用

<ul>
<li><strong>分析化学中的衍生化剂：</strong>利用LC-MRM-MS技术，将3-硝基苯基肼盐酸盐用作衍生化剂，用于检测感染单纯疱疹病毒1型的生物样品中的γ -羟基丁酸，从而增强法医和临床毒理学的检测能力（Osinaga等人，2022）。</li>
<li><strong>药物配方中的残留分析：</strong>该化合物还可用于氯霉素及其制剂中残留的4-硝基苯甲醛的定量分析，采用3-硝基苯肼衍生化后的高效液相色谱-紫外/可见检测，为保证药品的纯度和安全性提供了可靠的方法（Luo et al., 2018）。</li>
<li><strong>法医在分解分析中的应用：</strong>用于衍生化法医尸检时采集的血液样本（Matoba et al., 2022）。</li>
</ul>

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
SDBB3383
STBL4099
STBL1561
STBL1699
STBK8526

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Derivatization of N-acyl glycines by 3-nitrophenylhydrazine for targeted metabolomics analysis and their application to the study of diabetes progression in mice
Xiang, Li and Ru, et al.
Analytical Chemistry, 95, 2183-2191 (2023)
Lin-Xiu Guo et al.
Molecules (Basel, Switzerland), 25(23) (2020-12-10)
Short-chain fatty acids (SCFAs) are the main microbial fermentation products from dietary fibers in the colon, and it has been speculated that they play a key role in keeping healthy in the whole-body. However, differences in SCFAs concentration in the
François-Xavier Danlos et al.
Cell death & disease, 12(3), 258-258 (2021-03-13)
The circulating metabolome provides a snapshot of the physiological state of the organism responding to pathogenic challenges. Here we report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed
Isotope-labeling derivatization with 3-nitrophenylhydrazine for LC/multiple-reaction monitoring-mass-spectrometry-based quantitation of carnitines in dried blood spots
Han, Jun and Higgins, et al.
Analytica Chimica Acta, 1037, 177-187 (2018)
Michele Dei Cas et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1154, 121982-121982 (2020-08-31)
Short and medium fatty acids derived from either dietary sources, gut microbiota, and liver production might play a role in the modulation of metabolism and inflammation. The outcome of different autoimmune or inflammatory diseases could be related to microbiota composition
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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