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重要文件

G8503

Sigma-Aldrich

18α-甘草次酸

≥95%

同義詞:

18α-甘草次酸, 18-异甘草次酸, 3β-Hydroxy-11-oxo-18α,20β-olean-12-en-29-oic acid

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About This Item

經驗公式(希爾表示法):
C30H46O4
CAS號碼:
分子量::
470.68
EC號碼:
MDL號碼:
分類程式碼代碼:
12352115
PubChem物質ID:
NACRES:
NA.22
暫時無法取得訂價和供貨情況

品質等級

化驗

≥95%

SMILES 字串

[H][C@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)C4[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O

InChI

1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1

InChI 密鑰

MPDGHEJMBKOTSU-PMTKVOBESA-N

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一般說明

18α-甘草次酸 (18α-GA) 是一种在甘草中发现的具有生物活性的三萜类化合物。[1]其显示对 11-HSD1(11-羟基类固醇脱氢酶 1)的选择性抑制。[2]其对肝星状细胞 (HSC) 也有抗增殖和凋亡作用。[3]

應用

18α-甘草次酸可用于合成:[4]
  • 3-酮-18α-甘草次酸
  • 18α-甘草次酸甲酯
  • 3-酮基-18α-甘草次酸甲酯

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

防範說明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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存取文件庫

Selective inhibition of 11?-hydroxysteroid dehydrogenase 1 by 18a-glycyrrhetinic acid but not 18?-glycyrrhetinic acid.
Classen-Houben D, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 113(3), 248-252 (2009)
Sebastian M Goerke et al.
Tissue engineering. Part A, 18(23-24), 2395-2405 (2012-06-27)
Neovascularization represents an important issue in tissue-engineering applications, since survival of implanted cells strongly relies on sufficient oxygen and nutrient supply. We have recently observed that human bone marrow-derived mesenchymal stem cells (MSCs) support neovessel formation originating from coimplanted endothelial
A simple method for preparation of 18a-glycyrrhetinic acid and its derivatives.
Ignatov DV, et al.
Russian Journal of Bioorganic Chemistry, 29(4), 390-394 (2003)
Mohammad Shahidullah et al.
American journal of physiology. Cell physiology, 302(12), C1751-C1761 (2012-04-12)
In several tissues, transient receptor potential vanilloid 4 (TRPV4) channels are involved in the response to hyposmotic challenge. Here we report TRPV4 protein in porcine lens epithelium and show that TRPV4 activation is an important step in the response of
Manuel Viotti et al.
PLoS biology, 10(3), e1001276-e1001276 (2012-03-14)
Establishment of left-right (LR) asymmetry occurs after gastrulation commences and utilizes a conserved cascade of events. In the mouse, LR symmetry is broken at a midline structure, the node, and involves signal relay to the lateral plate, where it results

Questions

1–3 of 3 Questions  
  1. What is the stability of Product G8503, 18α-Glycyrrhetinic acid, once in solution?

    1 answer
    1. Unfortunately, we don't have any solution stability data available for this product.

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  2. What is the solubility of Product G8503, 18α-Glycyrrhetinic acid?

    1 answer
    1. It is soluble in chloroform:ethanol (2:3) at a concentration of 20 mg/mL.  It is expected to be soluble in dimethyl sulfoxide (DMSO) as well.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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