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重要文件

79625

Sigma-Aldrich

N,N-二甲基磷氨基二氯化物

≥98.0% (AT)

同義詞:

DMPADC, 二甲基氨基二氯化磷

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About This Item

線性公式:
(CH3)2NP(O)Cl2
CAS號碼:
分子量::
161.95
Beilstein:
969956
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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品質等級

化驗

≥98.0% (AT)

形狀

liquid

折射率

n20/D 1.464

bp

77-79 °C/11 mmHg (lit.)

密度

1.362 g/mL at 20 °C (lit.)

官能基

phosphoramide

儲存溫度

2-8°C

SMILES 字串

CN(C)P(Cl)(Cl)=O

InChI

1S/C2H6Cl2NOP/c1-5(2)7(3,4)6/h1-2H3

InChI 密鑰

YNHXBEVSSILHPI-UHFFFAOYSA-N

應用

N,N-Dimethylphosphoramic dichloride can be used as a reagent:
  • For the activation of carboxylic acids.[1][2]
  • To prepare functionalized β-lactams by reacting with acetic acids and imines.[2]
  • To synthesize phosphoramidic esters by reacting with alcohols in the presence of a base catalyst.[3]
  • To prepare [1,2,4]triazolo[4,3-c][1,3,5,2]triazaphosphinine-5-oxide derivatives by reacting with N-alkyl/aryl-N′-(4H-1,2,4-triazol-3-yl) amidines in the presence of triethylamine.[4]

象形圖

Corrosion

訊號詞

Danger

危險聲明

危險分類

Skin Corr. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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分析證明 (COA)

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H.J. Liu et al.
Tetrahedron Letters, 4461-4461 (1978)
A solid supported, rapid and mild synthesis of CWC related phosphoramidates
Shakya P, et al.
Catalysis Communications, 6, 669-673 (2005)
F.P. Cossio et al.
Tetrahedron Letters, 28, 1945-1945 (1987)
Convenient procedures for esterification of carboxylic acids
Hsing-Jang L, et al.
Tetrahedron Letters, 19, 4461-4464 (1978)
A new route to [1, 2, 4] triazolo [4, 3-c][1, 3, 5, 2] triazaphosphinine-5-oxides: reactivity of N-alkyl/aryl-n'-(4h-1, 2, 4-triazol-3-yl) amidines with N, N-dimethylphosphoramic dichloride
Hajr A and Marzouki L
Bulletin of the Chemical Society of Ethiopia, 34, 157-161 (2020)

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