跳轉至內容
Merck
全部照片(4)

重要文件

302309

Sigma-Aldrich

2-氰乙基N,N-二异丙基氯亚磷酰胺

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Cl 13.5-15.5 %

同義詞:

氯代(二异丙基氨基)-β-氰基乙氧基膦

登入查看組織和合約定價


About This Item

線性公式:
[(CH3)2CH]2NP(Cl)OCH2CH2CN
CAS號碼:
分子量::
236.68
Beilstein:
3588525
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
暫時無法取得訂價和供貨情況

形狀

liquid

成份

Cl, 13.5-15.5%

折射率

n/D 1.476-1.480

bp

103 -105 °C/0.1 hPa

密度

1.061 g/mL at 25 °C (lit.)

官能基

amine
nitrile

儲存溫度

−20°C

SMILES 字串

CC(C)N(C(C)C)P(Cl)OCCC#N

InChI

1S/C9H18ClN2OP/c1-8(2)12(9(3)4)14(10)13-7-5-6-11/h8-9H,5,7H2,1-4H3

InChI 密鑰

QWTBDIBOOIAZEF-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

應用

使用2-氰基乙基,N,N-二异丙基氯代亚磷酰胺
  • 用于碳水化合物和核苷的选择性单磷酸化[1]
  • 用于将受保护的核糖核苷转化为磷酰胺[2]
  • 作为 3′ 的磷酸化试剂-寡脱氧核苷酸合成中的羟基[3][4][5][6]
  • 在可放大的液相寡核苷酸合成中,使用亚磷酰胺化学和 DMT-、iBu-和 Bz-保护的单体。通过提取分离中间体,无需进一步纯化[7]

相關產品

產品號碼
描述
訂價

象形圖

FlameCorrosion

訊號詞

Danger

危險聲明

危險分類

Eye Dam. 1 - Pyr. Liq. 1 - Skin Corr. 1B

儲存類別代碼

4.2 - Pyrophoric and self-heating hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

230.0 °F - closed cup

閃點(°C)

110 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Organic Process Research & Development, 10, 1238-1238 (2006)
Yousef Ahmadibeni et al.
The Journal of organic chemistry, 70(3), 1100-1103 (2005-01-29)
Two classes of aminomethyl polystyrene resin-bound linkers of p-acetoxybenzyl alcohol were subjected to reactions with 2-cyanoethyl N,N-diisopropylchlorophosphoramidite to produce the corresponding polymer-bound phosphitylating reagents. These were reacted with a number of unprotected nucleosides and carbohydrates in the presence of 1H-tetrazole.
Tetrahedron Letters, 34, 6189-6189 (1993)
Tetrahedron Letters, 45, 509-509 (2004)
A Ono et al.
Bioconjugate chemistry, 4(6), 499-508 (1993-11-01)
Novel 2'-deoxyuridine analogues carrying aminoalkyl linkers at the 1'-position of the sugar residues were synthesized and incorporated into oligonucleotides, then intercalating groups such as an anthraquinone derivative and a pyrene derivative were attached to the amino groups. Duplexes consisting of

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

Reviews

Active Filters

  1. 1 Ratings-Only Review

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務