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PAMAM 树枝状聚合物，乙二胺核，4.0 代 溶液

10 wt. % in methanol

同義詞:

Starburst树枝状聚合物第4代

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About This Item

線性公式:
[NH2(CH2)2NH2]:(G=4);dendri PAMAM(NH2)64
CAS號碼:
163442-67-9
分子量：:
14214.17
MDL號碼:
MFCD00197936
分類程式碼代碼:
12162002
NACRES:
NA.23
暫時無法取得訂價和供貨情況

描述

amino surface groups

形狀

solution

分子量

generation 4.0

特點

core type ethylenediamine core (2-carbon core)

濃度

10 wt. % in methanol

號表面基團

64

折射率

n20/D 1.348

bp

64.7 °C

密度

0.813 g/mL at 25 °C

儲存溫度

2-8°C

相關類別

一般說明

PAMAM树枝状聚合物，乙二胺核，4代溶液是酰胺—胺聚合物，属于树枝状聚合物。可通过两步法的界面交互反应形成围绕乙二胺中心核的代而进行制备。它含有通过正规“支化再支化”模式组装的氮和酰胺官能团。它主要用作高容量螯合剂。[1][2]

應用

PAMAM树枝状聚合物，乙二胺核，4代溶液可作为引起DNA分子构象变化的压缩剂。[3]它可结合纤维素底物，构建可用于免疫检测的生物功能表面。[4]它可用于MRI对比剂[5]和二氧化硅纳米球的冷凝制备。[6]

外觀

含有 64 个表面伯氨基

法律資訊

由 Dendritech® 公司制造
Dendritech is a registered trademark of Dendritech, Inc.

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 3

閃點（°F）

51.8 °F - closed cup

閃點（°C）

11 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
MKCW0601
MKCV6531
MKCV1834
MKCS6102
MKCS4491

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Felipe Vidal et al.
Molecular pharmaceutics, 13(10), 3395-3403 (2016-08-25)
Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with
DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation
Ainalem M, et al.
PLoS ONE, 9(3), e92692-e92692 (2014)
Rolando Alberto Rodríguez-Fonseca et al.
Colloids and surfaces. B, Biointerfaces, 177, 77-93 (2019-02-04)
Peptide epitopes have been widely used to develop synthetic vaccines and immunotherapies. However, peptide epitopes may exhibit poor absorption or immunogenicity due to their low molecular weights. Conversely, fourth-generation polyamidoamine (G4-PAMAM) dendrimers are nonimmunogenic and relatively nontoxic synthetic nanoparticles that
Dendritic chelating agents. 1. Cu (II) binding to ethylene diamine core poly (amidoamine) dendrimers in aqueous solutions
Diallo MS, et al.
Langmuir, 20(7), 2640-2651 (2004)
Marc R Knecht et al.
Langmuir : the ACS journal of surfaces and colloids, 20(11), 4728-4732 (2005-06-23)
In diatoms, silica synthesis occurs by use of complex posttranslationally modified peptides, termed silaffins, and highly complex biological polyamine structures. Silaffin peptides have lysine residues that are modified to long-chain polyamine moieties of N-methyl derivatives of polypropylenimine to drive silica
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文章

Solubility Enhancement with Dendrimers

Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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