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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
predicted mol wt 30 kDa
物種活性
rat, human, mouse
技術
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HVCN1(84329)
一般說明
Hydrogen voltage gated channel 1 (HVCN1) is a voltage gated proton channel and is needed for efflux of intracellular acid. The gene encoding it is localized on human chromosome 12q24.11.
免疫原
HVCN1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human HVCN1.
生化／生理作用
Hydrogen voltage gated channel 1 (HVCN1) modulates insulin secretion by participating in Ca2+ homeostasis. In mice, the channel is involved in superoxide generation, bacterial removal from granulocytes and neutrophils and superoxide-associated B-cell receptor (BCR) signaling. HVCN1 might be associated with BCR-mediated B-cell malignancies.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
聯結
The action of this antibody can be blocked using blocking peptide SBP3500536.
外觀
Supplied in PBS with 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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相關產品
儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Elaine Hayes et al.
Frontiers in immunology, 11, 600033-600033 (2021-01-05)
Studies have endeavored to understand the cause for impaired antimicrobial killing by neutrophils of people with cystic fibrosis (PWCF). The aim of this study was to focus on the bacterial phagosome. Possible alterations in degranulation of cytoplasmic granules and changes
Padraig Hawkins et al.
Medicina (Kaunas, Lithuania), 57(8) (2021-08-28)
Background and Objectives: Alpha-1 antitrypsin is a serine protease inhibitor that demonstrates an array of immunomodulatory functions. Individuals with the genetic condition of alpha-1 antitrypsin deficiency (AATD) are at increased risk of early onset emphysematous lung disease. This lung disease
Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells.
Hondares E
Proceedings of the National Academy of Sciences of the USA (2014)
Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology
Tamara S
Antioxidants & Redox Signaling (2015)
Hv1 proton channel opening is preceded by a voltage-independent transition.
Villalba-Galea CA
Biophysical Journal (2014)
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