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方案
≥98% (HPLC)
表单
powder
颜色
off-white to light tan
溶解性
DMSO: ≥10 mg/mL
储存温度
room temp
SMILES字符串
Brc1ccc(NC(=O)c2ccc(Br)c(c2)S(=O)(=O)NCc3ccccc3)cc1
InChI
1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
InChI key
SWKAVEUTKGKHSR-UHFFFAOYSA-N
应用
RS-1已被：
- 作为同源介导修复(HDR)激动剂，研究对人造血干细胞/祖细胞的影响(HSPC)[1]
- 作为HDR激动剂，分析其对人诱导多能干细胞(iPS) DNA修复调节的影响[2]
- 作为RAD51激动剂，研究对双链断裂修复的影响[3]
RS-1显示出具有提高CRISPR基因组编辑效率的作用。欲了解其他CRISPR增强剂小分子，请访问 sigma.com/CRISPR-enhancers
生化/生理作用
RS-1 是人同源重组蛋白 RAD51 的刺激物。
RS-1是一种磺酰胺-苯甲酰胺化合物。[4]
RS-1（RAD51-刺激性化合物1）是人同源重组（HR）蛋白 RAD51 的刺激物。RS-1 刺激 hRAD51 与单链 DNA（ssDNA）的结合，并且在不抑制 hRAD51 ATP 酶活性的情况下，通过稳定 hRAD51 微丝的活性形式来增强重组活性。研究表明，RS-1 可增强 HEK293A 细胞中 CRISPR-Cas9 的敲入效率，并且在兔中，它可以提高 TALEN 和 cas9 介导的敲入效率。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
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International journal of molecular sciences, 22(4) (2021-03-07)
Fumarylacetoacetate hydrolase (FAH) is the fifth enzyme in the tyrosine catabolism pathway. A deficiency in human FAH leads to hereditary tyrosinemia type I (HT1), an autosomal recessive disorder that results in the accumulation of toxic metabolites such as succinylacetone, maleylacetoacetate
商品
业内研究了CRISPR基因组编辑背景下的HDR调控，发现各种细胞类型中增强CRISPR介导的HDR效率的小分子。
Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.
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