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A2169

Sigma-Aldrich

3′-叠氮-3′-脱氧胸苷

≥98% (HPLC), powder, reverse transcriptase inhibitor

别名:

AZT, ZDV, 叠氮胸苷, 齐多夫定

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25 MG
$195.00
100 MG
$416.00
250 MG
$766.00
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$2,450.00

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25 MG
$195.00
100 MG
$416.00
250 MG
$766.00
1 G
$2,450.00

About This Item

经验公式（希尔记法）:
C10H13N5O4
CAS号:
30516-87-1
分子量:
267.24
Beilstein:
3595791
MDL编号:
MFCD00006536
UNSPSC代码:
12352200
PubChem化学物质编号:
24278143
NACRES:
NA.77

$195.00

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产品名称

3′-叠氮-3′-脱氧胸苷, ≥98% (HPLC)

方案

≥98% (HPLC)

表单

powder

mp

113-115 °C (lit.)

溶解性

H2O: 50 mg/mL

储存温度

−20°C

SMILES字符串

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

基因信息

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

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应用

3′-叠氮-3′-脱氧胸苷已作为逆转录酶抑制剂抑制病毒基因组整合[1]和作为抗菌剂评估其抗沙门氏菌活性。[2]

生化/生理作用

叠氮胸苷 (AZT) 是一种胸苷类似物，是 HIV-1 病毒的逆转录酶抑制剂。叠氮胸苷已被证明会降低 CRISPR 介导的同源定向修复 (HDR) 的效率。
对 HIV-1 病毒有效的逆转录酶抑制剂。

特点和优势

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H341,H351

危险分类

Carc. 2 - Muta. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCW0371
MKCW5948
MKCS1355
MKCR8766
MKCQ4508

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Nature communications, 11(1), 330-330 (2020-01-18)
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Neuro-oncology, 12(6), 549-558 (2010-02-16)
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Questions

  1. For the use of this product in cell culture, what would be the best conditions for making stock solutions. Solvent, concentration, filtering, storage temp etc.?

    1 answer

    1. Unfortunately, this product has not been tested for cell culture applications. This compound is soluble at 50 mg/mL in water. For use in cell culture, the stock solution should be filter sterilized. Syringe filter product SLGVR33RS may be of interest. The pharmaceutical literature suggests that the stock solution is stable for 1 day at room temperature and 2 days if refrigerated.

      See the link below to a publication (page 3) regarding the stability of AZT in solution:
      https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019910s041lbl.pdf

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