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Merck

N3501

Sigma-Aldrich

β-烟酰胺单核苷酸

≥95% (HPLC)

别名:

β-NMN, β-烟酰胺核糖单磷酸, NMN, 烟酰胺-1-ium-1-β-D-呋喃糖苷5′-磷酸, 烟酰胺核苷酸

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About This Item

经验公式(希尔记法):
C11H15N2O8P
CAS号:
分子量:
334.22
Beilstein:
3570187
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

化驗

≥95% (HPLC)
≥95% (spectrophotometric assay)

形狀

powder

儲存溫度

−20°C

SMILES 字串

C[C@H]1[C@@H](C)[C@@H](O[C@@H]1COP(O)([O-])=O)[n+]2cccc(c2)C(N)=O

InChI

1S/C13H19N2O6P/c1-8-9(2)13(21-11(8)7-20-22(17,18)19)15-5-3-4-10(6-15)12(14)16/h3-6,8-9,11,13H,7H2,1-2H3,(H3-,14,16,17,18,19)/t8-,9+,11+,13+/m0/s1

InChI 密鑰

YYNOOWWEYJELSF-SEMCEJNYSA-N

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一般說明

β-烟酰胺单核苷酸 (β-NMN)是烟酰胺磷酸核糖基转移酶 (NAMPT)催化烟酰胺腺嘌呤二核苷酸 (NAD+)生物合成的中间体。 NAMPT可介导烟酰胺与5-磷酸核糖基-1-焦磷酸的缩合,生成β-NMN。 β-NMN腺苷酸转移酶随后将β-NMN转化为NAD+。

應用

β-烟酰胺单核苷酸(NMN)用于研究过RNA适体的结合基元,和包含了β烟酰胺单核苷酸 (β-NMN)-活化RNA片段的核酸酶活化过程。

其他說明

注:这是NMN常见形式。不要和 α-NMN混淆。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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C T Lauhon et al.
Journal of the American Chemical Society, 117(4), 1246-1257 (1995-02-01)
RNA molecules that specifically bind riboflavin (Rb) and beta-nicotinamide mononucleotide (NMN) have been isolated by in vitro selection. A simple structural motif containing intramolecular G-quartets was found to bind tightly to oxidized riboflavin (Kd = 1-5 micromolar). DNA versions of
João Meireles Ribeiro et al.
Scientific reports, 8(1), 1036-1036 (2018-01-20)
Cyclic ADP-ribose (cADPR) is a messenger for Ca
Tomoko Kito et al.
Drug metabolism and pharmacokinetics, 34(1), 87-94 (2018-12-12)
The purpose of this study was to elucidate the involvement of Mate1 in the tubular secretion of trimethoprim and saturation of Mate1-mediated efflux to address the mechanisms underlying the pharmacokinetic drug interactions with trimethoprim. Trimethoprim is a more potent inhibitor
Sophia E Airhart et al.
PloS one, 12(12), e0186459-e0186459 (2017-12-07)
The co-primary objectives of this study were to determine the human pharmacokinetics (PK) of oral NR and the effect of NR on whole blood nicotinamide adenine dinucleotide (NAD+) levels. Though mitochondrial dysfunction plays a critical role in the development and
Kazuhiro Hasegawa et al.
Nature medicine, 19(11), 1496-1504 (2013-10-22)
Sirtuin 1 (Sirt1), a NAD(+)-regulated deacetylase with numerous known positive effects on cellular and whole-body metabolism, is expressed in the renal cortex and medulla. It is known to have protective effects against age-related disease, including diabetes. Here we investigated the

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