This product is also soluble in water at 10mg/ml. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/195/258/p4020pis.pdf
推荐产品
产品名称
精蛋白 硫酸盐 来源于鲑鱼, Grade X, amorphous powder
类型
Grade X
表单
amorphous powder
杂质
histone, free (Millon test)
颜色
white to off-white
溶解性
6 M HCl: 25 mg/mL
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应用
与由Esterquat-1组成的具有可比性的固体脂质纳米颗粒（SLN）相比，SLN形式的鱼精蛋白可更有效地促进质粒DNA的转染，而且细胞毒性更低。
可用于从蛋白样品中去除DNA或用于纯化DNA结合蛋白。可用作逆转录病毒介导的基因转移中聚凝胺的替代物。
与由Esterquat-1组成的具有可比性的固体脂质纳米颗粒（SLN）相比，SLN形式的鱼精蛋白可更有效地促进质粒DNA的转染，而且细胞毒性更低。
与由Esterquat-1组成的具有可比性的固体脂质纳米颗粒（SLN）相比，SLN形式的鱼精蛋白可更有效地促进质粒DNA的转染，而且细胞毒性更低。
生化/生理作用
硫酸鱼精蛋白是一种可与 DNA 结合并产生沉淀的小阳离子蛋白。它能中和肝素的抗凝血活性，还可抑制脂蛋白脂肪酶。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Diazeniumdiolation of protamine sulfate reverses mitogenic effects on smooth muscle cells and fibroblasts
Van Lith R, et al.
Free radical biology & medicine, 82, 13-21 (2015)
Steve N Bailey et al.
Nature methods, 3(2), 117-122 (2006-01-25)
Here we describe lentivirus-infected cell microarrays for the high-throughput screening of gene function in mammalian cells. To create these arrays, we cultured mammalian cells on glass slides 'printed' with lentiviruses pseudotyped as vesicular stomatitis virus glycoprotein, which encode short hairpin
The design and evaluation of heparin-binding foldamers.
Sungwook Choi et al.
Angewandte Chemie (International ed. in English), 44(41), 6685-6689 (2005-08-12)
Microarrays of lentiviruses for gene function screens in immortalized and primary cells
Bailey SN, et al.
Nature Methods, 3(2), 117-117 (2006)
Wenjie Ouyang et al.
Human gene therapy, 32(9-10), 481-494 (2020-12-02)
β-Thalassemia is one of the most prevalent genetic diseases worldwide. The current treatment for β-thalassemia is allogeneic hematopoietic stem cell transplantation, which is limited due to lack of matched donors. Gene therapy has been developed as an alternative therapeutic option
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Are there other solvents besides 6M HCl to bring protamine sulfate salt into solution?
1 answer-
Helpful?
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Bonjour, Pourriez vous me confirmer qu'il s'agit bien d'un polypeptide et de combien d'unité de monomère est il formé ? Pourriez vous m'envoyer la représentation de la molécule ? merci
1 answer-
Unfortunately, structural studies on for this product have not been performed. However, regarding structure characterization and molecular representation of protamine from salmon, the following publication may be of interest for reference.
J Biol Chem. 1959 Sep:234:2314-6.
Physical and chemical properties of protamine from the sperm of salmon (Oncorhynchus tschawytscha). II. Anion binding characteristics
https://pubmed.ncbi.nlm.nih.gov/13807973/Helpful?
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