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Merck

N7764

Sigma-Aldrich

烟酸单核苷酸

别名:

Nicotinate mononucleotide

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5 MG
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5 MG
$240.00
10 MG
$496.00
25 MG
$742.00
100 MG
$2,510.00

About This Item

经验公式(希尔记法):
C11H14NO9P
CAS号:
分子量:
335.20
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.79

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生物源

animal

品質等級

化驗

≥98.0% (HPLC)

形狀

powder

技術

HPLC: suitable

顏色

white

儲存溫度

−20°C

SMILES 字串

OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O

InChI

1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)

InChI 密鑰

IUJWGLOJJKFASX-UHFFFAOYSA-N

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一般說明

烟酸单核苷酸(NaMN)是在存在磷酸核糖基转移酶(NaPRT)的情况下,由烟酸5-磷酸核糖基-1-焦磷酸(PRPP)通过Preiss-Handler途径形成的。[1]

應用

烟酸单核苷酸已被用作烟酰胺腺嘌呤二核苷酸(NAD)生物合成过程中NMN / NaMN腺苷转移酶(NMNAT)的底物。[2]

生化/生理作用

烟酸单核苷酸(NaMN)可用于研究酵母中磷酸盐响应信号(PHO)途径与烟碱腺嘌呤二核苷酸(NAD(+))代谢之间的关系。 [3] 烟酸酯单核苷酸是NMN / NaMN腺苷转移酶(NMNAT)[4]和烟酸酯单核苷酸腺苷转移酶的底物。[5]NaMN酰胺化导致烟酰胺单核苷酸(NMN)的合成,其可进一步转化为NAD辅因子。[6]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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William B Black et al.
Microbial cell factories, 19(1), 150-150 (2020-07-29)
Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible. However, these noncanonical redox cofactors need to be biologically synthesized to achieve
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy
Sasaki Y, et al.
Journal of neurosciences in rural practice, 26(33), 8484-8491 (2006)
Crystal structure of human nicotinic acid phosphoribosyltransferase
Marletta AS, et al.
FEBS Open Bio, 5, 419-428 (2015)
Shu-Ping Lu et al.
The Journal of biological chemistry, 286(16), 14271-14281 (2011-02-26)
Nicotinamide adenine dinucleotide (NAD(+)) is an essential cofactor involved in various cellular biochemical reactions. To date the signaling pathways that regulate NAD(+) metabolism remain unclear due to the dynamic nature and complexity of the NAD(+) metabolic pathways and the difficulty
D Sun et al.
Journal of bacteriology, 175(5), 1423-1432 (1993-03-01)
A number of Bacillus subtilis genes involved in NAD biosynthesis have been cloned and sequenced. One of the genes encodes a polypeptide homologous to Escherichia coli L-aspartate oxidase, and its mutation resulted in a nicotinic acid (Nic)-dependent phenotype; this gene

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