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H5160

Sigma-Aldrich

贯叶金丝桃素

≥85% (HPLC)

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250 μG
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250 μG
$307.00

About This Item

经验公式（希尔记法）:
C35H52O4
CAS号:
11079-53-1
分子量:
536.78
EC 号:
200-659-6
MDL编号:
MFCD01861497
UNSPSC代码:
12352200
PubChem化学物质编号:
329815216
NACRES:
NA.77

$307.00

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质量水平

100

方案

≥85% (HPLC)

表单

solution

储存温度

−20°C

SMILES字符串

CC(C)C(=O)[C@@]12C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(/C)C)(C[C@H](C\C=C(\C)C)[C@@]1(C)CC\C=C(\C)C)C2=O

InChI

1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1

InChI key

IWBJJCOKGLUQIZ-HQKKAZOISA-N

一般描述

贯叶金丝桃素是圣约翰′草的一种间苯三酚成分，同时也是一种孕烷 X 受体配体。[1]

应用

贯叶金丝桃素可用于：
  • 作为参考标准品用于制定高效液相色谱 (HPLC) 分析的校准曲线[2]
  • 测试其对小鼠他胚胎细胞的细胞毒性作用和诱导细胞凋亡作用[3]
  • 作为猪脑毛细血管内皮细胞孕烷X受体 (PXR) 用于传递检测[4]

生化/生理作用

贯叶金丝桃素是一种活性抗抑郁剂[2]和细胞色素P450 3A4 (CYP3A) 抑制剂。[1]它可诱导抗氧化和抗细菌活性。贯叶金丝桃素还具有胚胎毒性并抑制肿瘤增生。[3]它可有效抑制多巴胺、血清素和去甲肾上腺素。[1]

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCW9512
MKCV6897
MKCW1054
MKCR4426
MKCR4755

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L B Moore et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(13), 7500-7502 (2000-06-15)
St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of depression. Recent clinical studies demonstrate that hypericum extracts increase the metabolism of various drugs, including combined oral contraceptives, cyclosporin, and indinavir. In this report, we
Murhaf Zaher et al.
International journal of oncology, 40(1), 269-276 (2011-09-29)
We previously reported that hyperforin, a phloroglucinol purified from Hypericum perforatum, induces the mitochondrial pathway of caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells ex vivo, and that this effect is associated with upregulation of Noxa, a BH3-only protein of
Mohamed A Farag et al.
Planta medica, 78(5), 488-496 (2012-01-25)
The growing interest in the efficacy of phytomedicines and herbal supplements but also the increase in legal requirements for safety and reliable contents of active principles drive the development of analytical methods for the quality control of complex, multicomponent mixtures
Jeffry Adiwidjaja et al.
Clinical pharmacokinetics, 58(7), 911-926 (2019-01-25)
Herb-drug interactions with St John's wort (SJW) have been widely studied in numerous clinical studies. The objective of this study was to develop and evaluate a physiologically based pharmacokinetic (PBPK) model for hyperforin (the constituent of SJW responsible for interactions)
Determination of hypericin and hyperforin content in selected Jordanian Hypericum species
Tawaha K, et al.
Industrial Crops and Products, 32(3), 241-245 (2010)
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