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生物来源
synthetic
等级
pharmaceutical primary standard
Agency
EP
API类
tretinoin
表单
solid
制造商/商品名称
EDQM
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
mp
180-181 °C (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI key
SHGAZHPCJJPHSC-YCNIQYBTSA-N
基因信息
human ... RARA(5914) , RARB(5915) , RARG(5916)
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一般描述
应用
本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。
生化/生理作用
全−反式−视黄酸（ATRA）是视黄酸受体（RAR）和视黄醇类 X 受体（RXR）的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450（CYP）可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。
视黄酸受体（RAR）和类视黄醇X受体（RXR）的配体; 引发胚胎干细胞成为神经元。
包装
本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。
其他说明
可能适用相应的销售限制。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
其他客户在看
Tretinoin: The Active Retinoid Medication Used for Treatment of Acne Fast and Effectively (2019)
A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations
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Journal of Pharmaceutical and Biomedical Analysis, 43(3) (2007)
Bogdan Jakiela et al.
American journal of respiratory cell and molecular biology, 51(2), 229-241 (2014-03-05)
Human rhinoviruses (RVs) are a major cause of exacerbations in asthma and other chronic airway diseases. A characteristic feature of asthmatic epithelium is goblet cell metaplasia and mucus hypersecretion. Bronchial epithelium is also an important source of lipid mediators, including
Enrico Garattini et al.
Cancer treatment reviews, 40(6), 739-749 (2014-02-01)
All-trans retinoic acid (ATRA) is the most important active metabolite of vitamin A controlling segmentation in the developing organism and the homeostasis of various tissues in the adult. ATRA as well as natural and synthetic derivatives, collectively known as retinoids
Mathilde Raverdeau et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 2953-2958 (2014-03-25)
Retinoic acid (RA) is produced by a number of cell types, including macrophages and dendritic cells, which express retinal dehydrogenases that convert vitamin A to its main biologically active metabolite, all-trans RA. All-trans RA binds to its nuclear retinoic acid
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