PHL89262

槲皮素

phyproof^® Reference Substance

• 别名: 2-(3,4-二羟苯基)-3,5,7-三羟基-4H-1-苯并吡喃-4-酮, 3,3′,4′,5,6-五羟基黄酮
• 经验公式（希尔记法）: C₁₅H₁₀O₇
• CAS号: 117-39-5
• 分子量: 302.24
• Beilstein: 317313
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: primary reference standard
• 產品線: phyproof^® Reference Substance
• 化驗: ≥95.0% (HPLC)
• 製造商／商標名: PhytoLab
• 應用: food and beverages
• 格式: neat
• SMILES 字串: OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1
• InChI: 1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
• InChI 密鑰: REFJWTPEDVJJIY-UHFFFAOYSA-N

说明

一般說明

该物质是具有指定绝对纯度（考虑色谱纯度、水、残留溶剂、无机杂质）的一级参考物质。确切的值见证书。生产商：PhytoLab GmbH & Co. KG

應用

• Simultaneous determination of eight arginine-related metabolites in cellular extracts using liquid chromatography-tandem mass spectrometry.: This study utilized the Chromolith^® RP-18 endcapped column to achieve high-resolution separation of arginine-related metabolites in cellular extracts. The method demonstrated excellent reproducibility and sensitivity, highlighting the column′s effectiveness in complex biological sample analysis (Amatya S et al., 2020).


• Rapid Determination of 30 Polyphenols in Tongmai Formula, a Combination of Puerariae Lobatae Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Chuanxiong Rhizoma, via Liquid Chromatography-Tandem Mass Spectrometry.: The Chromolith^® RP-18 endcapped column was employed for the rapid and efficient determination of polyphenols in a traditional Chinese medicine formula. The column′s high throughput and robust performance facilitated the simultaneous analysis of multiple compounds, demonstrating its application in natural product research (Wang FR et al., 2017).


• Simultaneous Liquid Chromatographic Determination of Ebastine with Two Sympathomimetic Drugs Using a Monolithic Column.: This research applied the Chromolith^® RP-18 endcapped column to the simultaneous chromatographic determination of ebastine and two sympathomimetic drugs. The study underscored the column′s ability to provide rapid and efficient separations in pharmaceutical analysis, ensuring accurate quantification of drug components (Ibrahim F et al., 2017).

生化／生理作用

槲皮素是一种具有抗癌活性的黄酮类化合物。 槲皮素是一种线粒体ATP酶和磷酸二酯酶抑制剂。它抑制PI3激酶活性，并略抑制PIP激酶活性。槲皮素对癌细胞具有抗增殖作用，通过II型雌激素受体降低癌细胞生长，并在细胞周期G1晚期抑制人白血病T细胞。 槲皮素还可能抑制脂肪酸合酶活性。

其他說明

This compound is commonly found in plants of the genus: allium angelica arnica glycyrrhiza hypericum lycium sambucus

法律資訊

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3