价格与库存信息目前不能提供
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质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
运输
ambient
储存温度
2-8°C
一般描述
CRM197 is a nontoxic diphtheria toxin that has a glycine to glutamic acid mutation at amino acid 52 in fragment A, resulting in the complete loss of enzymatic activity. Does not catalyze the ADP ribosylation of EF-2 factor. Immunologically, the CRM197 protein is identical to the wild-type toxin.
Cross-reactive material of diphtheria toxin (CRM197). A nontoxic diphtheria toxin that has a glycine to glutamic acid mutation at amino acid 52 in fragment A that results in complete loss of enzymatic activity. Inhibits smooth muscle cell proliferation in a dose-dependent manner. Immunologically, the CRM197 is identical to the wild-type toxin and is useful as a carrier protein of conjugate vaccines.
生化/生理作用
Cell permeable: no
Primary Target
Mutant with loss of enzymatic activity to catalyze the ADP ribosylation of EF-2 factor
Mutant with loss of enzymatic activity to catalyze the ADP ribosylation of EF-2 factor
Reversible: no
警告
Toxicity: Standard Handling (A)
外形
Lyophilized from 10 mM sodium phosphate buffer, 5% lactose, pH 7.4.
重悬
Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 year at -70°C.
Please refer to vial label for lot-specific reconstitution volume.
分析说明
One major band by SDS-PAGE
其他说明
Kusano, I., et al. 2001. Cell Struct. Funct.26, 279.
Kaefer, M., et al. 2000. J. Urol.163, 580.
Gupta, R.K., et al. 1997. Vaccine15, 1341.
Bixler, G.S., et al. 1989. Adv. Exp. Med. Biol.251, 175.
Giannini, G., et al. 1984. Nucleic Acids Res.12, 4063.
Uchida, T., et al. 1973. J. Biol. Chem. 248, 3851.
Pappenheimer, Jr., A.M., et al. 1972. Immunochem. 9, 891.
Kaefer, M., et al. 2000. J. Urol.163, 580.
Gupta, R.K., et al. 1997. Vaccine15, 1341.
Bixler, G.S., et al. 1989. Adv. Exp. Med. Biol.251, 175.
Giannini, G., et al. 1984. Nucleic Acids Res.12, 4063.
Uchida, T., et al. 1973. J. Biol. Chem. 248, 3851.
Pappenheimer, Jr., A.M., et al. 1972. Immunochem. 9, 891.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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