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Merck

739979

Sigma-Aldrich

Resomer® RG 858 S,聚(D,L-丙交酯--乙交酯)

ester terminated, lactide:glycolide 85:15, Mw 190,000-240,000

别名:

PLGA

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1 G
$100.00
5 G
$324.00

About This Item

线性分子式:
[C3H4O2]x[C2H2O2]y
CAS号:
MDL编号:
UNSPSC代码:
12162002
NACRES:
NA.23

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质量水平

表单

amorphous

投料比

lactide:glycolide 85:15

分子量

Mw 190,000-240,000

降解时间线

<9 months

粘度

1.3-1.7 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

储存温度

2-8°C

SMILES字符串

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

一般描述

RESOMER®聚合物是生物可吸收的脂肪族聚酯,它由一系列不同比例的丙交酯和乙交酯单体、PLA立体化学和端基官能化组成。这些丙交酯和乙交酯的生物可降解均聚物和共聚物具有多种特性,其范围从降解时间长的刚性硬质半晶体材料到降解速率更快、更软的无定形材料。[1]

应用

Electrospun Resomer® X 206 S与来自甘蔗渣的纤维素混合,可用作组织工程中的支架。
控制释放

特点和优势

生物活性剂的控制释放、缝合线和生物可吸收性可植入装置。

法律信息

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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RESOMER??Biodegradeable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering
Mader K
Material Matters, 6(3), 62-62 (2011)
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Patrick Vavken et al.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 29(1), 122-132 (2012-12-04)
The objective of this study was to assess the effect of absorbable or nonabsorbable sutures in bioenhanced anterior cruciate ligament (ACL) repair in a skeletally immature pig model on suture tunnel and growth plate healing and biomechanical outcomes. Sixteen female

商品

Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

商业生物材料已停滞不前超过30年的时间,因为很少有材料能够成功地从实验台过渡到临床使用。合成型脂族聚酯因其悠久的历史和获得美国食品药品监督管理局(FDA)批准的记录,一直在可吸收生物材料领域占据主导地位。

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

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