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719897

Sigma-Aldrich

RESOMER® RG 502 H，聚（d，L-丙交酯-共-乙交酯）

Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide)
1 of 1 reviewers received a sample product or took part in a promotion

acid terminated, viscosity 0.16-0.24 dL/g 

别名:

PLGA, RESOMER® RG 502 H

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About This Item

线性分子式:
[C3H4O2]x[C2H2O2]y
CAS号:
26780-50-7
MDL编号:
MFCD00131930
UNSPSC代码:
12162002
NACRES:
NA.23

$144.00

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质量水平

200

表单

amorphous

投料比

lactide:glycolide 50:50

降解时间线

<3 months

粘度

0.16-0.24 dL/g

转变温度

Tg 42-46 °C

储存温度

2-8°C

SMILES字符串

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

相关类别

应用

聚（(D,L-丙交酯-co-乙交酯）（PLGA）可用于：

  • 为H2S供体配制非水药物递送系统，以促进药物的持续释放。
  • 制备含有分散于 PLGA–PEG–PLGA聚合物凝胶中的更昔洛韦微球的聚合物混合物。该制剂可用作更昔洛韦药物的持续给药系统。
它也可用于制造释放一氧化氮的葡萄糖和乳酸传感器。

法律信息

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

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储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX2944
MKCX2102
MKCV8978
BCCH1660
BCCG6651

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A Patil et al.
AAPS PharmSciTech, 18(6), 2291-2302 (2017-01-20)
Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy.
Diazeniumdiolate-doped poly (lactic-co-glycolic acid)-based nitric oxide releasing films as antibiofilm coatings.
Cai W,et al.
Biomaterials, 33(32), 7933-7944 (2012)
Sridhar Duvvuri et al.
Journal of controlled release : official journal of the Controlled Release Society, 108(2-3), 282-293 (2005-10-19)
The purpose of this work is to develop empirical equations for describing the in vitro ganciclovir (GCV) release from PLGA microspheres and also to develop and characterize a formulation containing GCV loaded PLGA microspheres dispersed in thermogelling PLGA-PEG-PLGA polymer gel.
Qinyi Yan et al.
Biosensors & bioelectronics, 26(11), 4276-4282 (2011-05-20)
Intravenous amperometric needle-type enzymatic glucose/lactate sensors intended for continuous monitoring are prepared with a novel nitric oxide (NO) releasing layer to improve device hemocompatibility. To create an underlying NO release coating, the sensors with immobilized enzymes (either glucose oxidase or
Z Zhuang et al.
Journal of dental research, 98(2), 200-208 (2018-11-06)
Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio
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商品

RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

Poly(Glycerol Sebacate) in Tissue Engineering

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

聚甘油癸二酸酯在组织工程和再生医学的应用

商业生物材料已停滞不前超过30年的时间，因为很少有材料能够成功地从实验台过渡到临床使用。合成型脂族聚酯因其悠久的历史和获得美国食品药品监督管理局（FDA）批准的记录，一直在可吸收生物材料领域占据主导地位。

Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

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Questions

1–4 of 4 Questions  

  1. Resomer® RG 502 H, Catalogue No.719897 Q1: Why the Molecular weight of this product is in a range from 7000-17000 and not fixed? Q2: How many COOH groups will be there for each molecule? Q3: Is PLGA made in random or alternative block design?

    1 answer

    1. Q1: The molecular weight range of 7000-17000 is a specification range, and the exact molecular weight is determined on a lot-to-lot basis, as listed on the Certificate of Analysis.

      Q2: The number of COOH groups per molecule is not tested. The acid value, which can be referenced, has a specification range of ≥ 6.0 mg KOH/g.

      Q3: This product is Poly(D,L-lactide-co-glycolide), where "-co-" indicates an unspecified arrangement. Information on block design is not available, and there is no Poly(D,L-lactide-ran-glycolide) or Poly(D,L-lactide-alt-glycolide) available.

      Helpful?

  2. Qual è il range di pesp molecolare di questo polimero?

    1 answer

    1. The Resomer RG group of products has a molecular weight range of 7000 - 240,000 daltons. The value is lot specific and reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
      https://www.sigmaaldrich.com/product/aldrich/719897#product-documentation

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  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  4. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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Reviews

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