This product includes 1 chip and the additional tubing, valves, and accessories required for use. The kit components, including the chip, are reusable. However, proper cleaning is required. Please see the link below to review the product usage instructions, including the cleaning protocol:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/105/115/911593pis-ms.pdf
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描述
Microfludic device kit for synthesizing nanparticles
Kit components :
- Microfluidic chip x 1
- Tubings and accessories
品質等級
應用
advanced drug delivery
一般說明
NanoFabTx™ 微流控纳米设备套件是一套即插即用的易用型微流控部件，兼容Dolomite 微流控系统和标准注射泵（未包括）。 该设备套件可结合我们的专用纳米制剂试剂盒使用（请浏览www.sigmaaldrich.com/nanofabtx）生成尺寸100至200nm 的纳米颗粒或脂质体。该设备套件包括全面的操作方案、预装式微流控芯片歧管、管道和必要的配件。
應用
NanoFabTx™ 微流控纳米设备套件要与NanoFabTx™纳米试剂盒（包括909637、918075和907766）一起使用，用于合成封装药物的脂质体纳米颗粒（LNP） 和封装药物的聚合物纳米颗粒进行靶向给药研究。我们的设备套件利用微流控技术实现窄尺寸分散和高批次间一致性，从而简化LNP制剂和聚合物纳米制剂的配制。微流控芯片歧管（chip manifold）化学性质稳定，可以兼容纳米医学中的各种相关溶剂和药物。微流控芯片的几何尺寸和可控制的流速让用户可以实现100至200纳米的目标颗粒直径、均一的形状和结构。我们基于微流控的工具帮助用户轻松调节合成参数，从而帮助精准医学、药物开发和纳米颗粒癌症治疗领域的科研人员实现封装药物的纳米载体的可扩展合成（scalable synthesis ）。
特點和優勢
- 我们的配方科学家开发和测试的基于微流控的分步操作方案
- 优化纳米颗粒和脂质体中的药物封装和装载效率
- 从100-200 nm的范围选择最佳纳米颗粒和脂质体尺寸
- 反应体积小以减少昂贵试剂和药物的浪费
法律資訊
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
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说明
价格
Samar Damiati et al.
Genes, 9(2) (2018-02-22)
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow
Andrew Gdowski et al.
Journal of nanobiotechnology, 16(1), 12-12 (2018-02-13)
The process of optimization and fabrication of nanoparticle synthesis for preclinical studies can be challenging and time consuming. Traditional small scale laboratory synthesis techniques suffer from batch to batch variability. Additionally, the parameters used in the original formulation must be
Xuanyu Li et al.
Advanced drug delivery reviews, 128, 101-114 (2017-12-27)
Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct properties by changing the precursors and the flow rates, significantly decreasing the time for screening optimal formulation as carriers for drug delivery compared to conventional methods.
商品
NanoFabTx™ platform accelerates drug development with ready-to-use formulations and microfluidic devices for particle synthesis.
NanoFabTX kits enable precise drug delivery with lipid nanoparticles and liposomes for mRNA and nucleic acids.
Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.
Microfluidic assembly improves polyamine nanoencapsulation of nucleic acids, overcoming challenges like polydispersity and poor reproducibility.
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Me podrían indicar si los chips son de un solo uso o reciclables? Cuántos chips entran en el kit?
1 answer-
Helpful?
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Can more information be provided on the material of construction for NanoFabTx microfluidic chip product 911593? Additionally, is this product compatible with ethyl acetate?
1 answer-
Regarding fluidic compatibility, the most effective approach to address this question is for a review of the fluidic pathway involved, after which compatibility can be verified. The components are as follows:
1.Tubing: PTFE/FEP – Resistant (A)
2.Chip: B270 Crown Glass – Resistant (A)
3.Linear Connector: PEEK – Resistant (A)
4.Linear Connector Seal: FFKM – Resistant (A)
5.Linear Connector Screws: Stainless Steel (316) - Resistant (B)
6.H-Interface: Aluminum - Resistant (A)
In general, the flow path demonstrates excellent resistance to ethyl acetate. It is advisable to flush the flow path with DI Water/IPA (filtered) before introducing a target solvent to ensure that the fluidic pathway is properly sealed and not leaking prior to use. Additionally, once the process is complete, flushing the solvent out of the system is recommended to ensure cleanliness and dryness.Helpful?
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