Mouse PLU-1, also known as JARID1B and KDM5B (GenBank Accession No. NM_152895), amino-acids 2-751 with N-terminal FLAG-tag, MW = 86 kDa, expressed in Sf9 cells via a Baculovirus expression system.
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Posttranslational modification of chromatin by histone methylation has wide-ranging effects on nuclear function, including transcriptional regulation, maintenance of genome integrity, and epigenetic inheritance. The enzymes utilized to place histone methylation marks are well characterized, but the identity of a histone
International journal of cancer, 121(2), 265-275 (2007-03-22)
The PLU-1/JARID1B nuclear protein, which is expressed in a high proportion of breast cancers, but shows restricted expression elsewhere, belongs to the ARID family of proteins, known to play important roles in development, differentiation, transcriptional regulation and chromatin remodeling. PLU-1/JARID1B
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