SRP0311
HDAC6 H611A human
recombinant, expressed in baculovirus infected Sf9 cells, ≥79% (SDS-PAGE)
Synonim(y):
HD6, JM21, histone deacetylase 6
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About This Item
Kod UNSPSC:
12352200
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in baculovirus infected Sf9 cells
Próba
≥79% (SDS-PAGE)
Postać
aqueous solution
masa cząsteczkowa
161 kDa
opakowanie
pkg of 50 μg
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... HDAC6(10013)
Opis ogólny
HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors. The mutation H611A results in catalytically inactive HDAC6.
Human HDAC6 with H611A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.
Human HDAC6 with H611A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.
Działania biochem./fizjol.
HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis. HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility. It is also involved in the formation of SGs (stress granules) and SG proteins. Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
HDAC11 is a novel drug target in carcinomas.
Deubzer HE, et al.
International Journal of Cancer. Journal International Du Cancer, 132, 2200-2200 (2013)
Li S. et al.
Neurology, 41, 112-116 (2010)
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.
Hook SS, et al.
Proceedings of the National Academy of Sciences of the USA, 99, 13425-13425 (2002)
Loss of a-Tubulin Acetylation Is Associated with TGF-?-induced Epithelial-Mesenchymal Transition.
Gu S, et al.
The Journal of Biological Chemistry, 291, 5396-5396 (2016)
Jiaqi Liu et al.
Journal of translational medicine, 14, 7-7 (2016-01-10)
Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inhibitors are small-molecule compounds without a specific target, and their mechanism
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