PF74 (PF-3450074) jest inhibitorem HIV-1, który celuje w białko kapsydu HIV.
PF74 (PF-3450074) jest inhibitorem HIV-1, który celuje w białko kapsydu HIV. PF74 wiąże się specyficznie z cząsteczkami HIV-1 i powoduje przedwczesne odklejanie się HIV-1 w komórkach docelowych.
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International journal of fertility, 37(5), 283-285 (1992-09-01)
Patients with complete androgen insensitivity syndrome rarely have Müllerian remnants. A patient with this syndrome found to have a microscopic fallopian tube at the time of gonadectomy is described and possible etiologies for the finding are discussed.
The HIV-1 capsid protein (CA) facilitates reverse transcription and nuclear entry of the virus. However, CA's role in post-nuclear entry steps remains speculative. We describe a direct link between CA and integration by employing the capsid inhibitor PF74 as a
Nuclear entry is a selective, dynamic process granting the HIV-1 pre-integration complex (PIC) access to the chromatin. Classical analysis of nuclear entry of heterogeneous viral particles only yields averaged information. We now have employed single-virus fluorescence methods to follow the
A major structural retroviral protein, capsid protein (CA), is able to oligomerize into two different hexameric lattices, which makes this protein a key component for both the early and late stages of HIV-1 replication. During the late stage, the CA
The HIV-1 capsid protein (CA) facilitates reverse transcription and nuclear entry of the virus. However, CA's role in post-nuclear entry steps remains speculative. We describe a direct link between CA and integration by employing the capsid inhibitor PF74 as a
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
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