G9145

[Leu¹⁵]-Gastrin I human

≥95% (HPLC)

• Synonim(y): [Leu¹⁵]-HG-17, LHG-17, [15-Leucine]-Gastrin I, human heptadecapeptide, [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human, [Leu¹⁵]-Gastrin I, human, [Leucine¹⁵]-Gastrin I heptadecapeptide, [Leucine¹⁵]-Little gastrin I
• Wzór empiryczny (zapis Hilla): C₉₈H₁₂₆N₂₀O₃₁
• Numer CAS: 39024-57-2
• Masa cząsteczkowa: 2080.16
• Beilstein: 5227423
• Numer WE: 254-250-2
• Numer MDL: MFCD00076502
• Kod UNSPSC: 12352209
• Identyfikator substancji w PubChem: 24895364
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• Poziom jakości: 200
• Próba: ≥95% (HPLC)
• Formularz: powder
• metody: cell culture | mammalian: suitable
• numer dostępu UniProt: P01350
• temp. przechowywania: −20°C
• ciąg SMILES: CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C3CCCN3C(=O)CNC(=O)C4CCC(=O)N4)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(Cc5ccc(O)cc5)C(=O)NCC(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc8ccccc8)C(N)=O
• InChI: 1S/C98H126N20O31/c1-49(2)38-68(115-96(147)72(43-55-46-101-60-19-12-10-17-58(55)60)117-98(149)74-20-13-37-118(74)77(122)48-103-86(137)61-25-31-75(120)105-61)93(144)111-66(30-36-82(131)132)92(143)110-65(29-35-81(129)130)91(142)109-64(28-34-80(127)128)90(141)108-63(27-33-79(125)126)89(140)107-62(26-32-78(123)124)88(139)104-51(5)85(136)113-70(41-53-21-23-56(119)24-22-53)87(138)102-47-76(121)106-71(42-54-45-100-59-18-11-9-16-57(54)59)95(146)114-69(39-50(3)4)94(145)116-73(44-83(133)134)97(148)112-67(84(99)135)40-52-14-7-6-8-15-52/h6-12,14-19,21-24,45-46,49-51,61-74,100-101,119H,13,20,25-44,47-48H2,1-5H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,120)(H,106,121)(H,107,140)(H,108,141)(H,109,142)(H,110,143)(H,111,144)(H,112,148)(H,113,136)(H,114,146)(H,115,147)(H,116,145)(H,117,149)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)
• Klucz InChI: CMVMLPDUAGUTOC-UHFFFAOYSA-N
• informacje o genach: human ... GAST(2520)

Opis

Amino Acid Sequence

Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

Opis ogólny

GAST gene encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2.[1] G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin.[1] Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR).[2] Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin. Gastric adenocarcinoma show high levels of gastrin.[1]

Zastosowanie

Gastrin has been used:

• as a medium supplement establish enteroid cultures[3]
• as a supplement to standard Dulbecco′s Modified Eagle Medium (DMEM) culture medium,[4][5] human minigut medium[6] to establish the growth of crypts.

Działania biochem./fizjol.

Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu¹⁵ replaces Met¹⁵, that is readily oxidized resulting in loss of biological activity.

Inne uwagi

Lyophilized from 0.1% TFA in H2O

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)