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Merck

SAB5600064

Sigma-Aldrich

Anti-Phospho-akt (ser473) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM251, purified immunoglobulin

Synonim(y):

phosphorylation at Ser473

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About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

rekombinowane

expressed in HEK 293 cells

Poziom jakości

forma przeciwciała

purified immunoglobulin

rodzaj przeciwciała

primary antibodies

klon

RM251, monoclonal
recombinant monoclonal

Postać

buffered aqueous glycerol solution

reaktywność gatunkowa

human

metody

immunoblotting: 1:1000-1:2000
immunohistochemistry: 1:200-1:500

izotyp

IgG

numer dostępu NCBI

Warunki transportu

wet ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

phosphorylation (pSer473)

informacje o genach

human ... AKT1(207)

Opis ogólny

AKT1 (AKT serine/threonine kinase 1) is also called as v-akt murine thymoma viral oncogene homolog 1 and PKB α (protein kinase B). It is expressed in liver,muscle and adipocytes. AKT1 gene is mapped to human chromosome 14q32. It is a member of AKT family that has an amino-terminal pleckstrin homology (PH) domain, a short α helical linker and a carboxyl-terminal kinase domain.

Specyficzność

This antibody reacts to Akt only when phosphorylated at Ser473. There is no cross-reactivity with Akt without phosphorylation at Ser473. This antibody may also react to bovine, mouse or rat Phospho-Akt (Ser473), as predicted by immunogen homology

Immunogen

Synthetic peptide corresponding to human Phospho-Akt (Ser473)

Działania biochem./fizjol.

AKT1 (AKT serine/threonine kinase 1) controls the survival of cells and anti-apoptotic actions that attack the pathogenesis of several cancers, hence it plays a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Postać fizyczna

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.
Liu JM, et al.
Genetics and molecular research : GMR, 16(1) (2017)
Claudia Delgadillo-Puga et al.
Nutrients, 15(11) (2023-06-10)
Pecans (Carya illinoinensis) are considered a functional food due to the high content of polyunsaturated fatty acids, dietary fiber and polyphenols. To determine the effect of whole pecans (WP) or a pecan polyphenol (PP) extract on the development of metabolic
Eun-Hui Lee et al.
Scientific reports, 8(1), 9894-9894 (2018-07-04)
Accumulating data have indicated a fundamental role of eosinophils in regulating adipose tissue homeostasis. Here, we performed whole-genome RNA sequencing of the small intestinal tract, which suggested the presence of impaired lipid metabolism in eosinophil-deficient ΔdblGATA mice. ΔdblGATA mice fed
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
Cho H, et al.
The Journal of Biological Chemistry, 276(42), 38349-38352 (2001)
AKT plays a central role in tumorigenesis
Testa JR and Bellacosa A
Proceedings of the National Academy of Sciences of the USA, 98(20), 10983-10985 (2001)

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