SAB4504031
Anti-phospho-IRF-3 (pSer396) antibody produced in rabbit
affinity isolated antibody
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About This Item
Kod UNSPSC:
12352203
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
rabbit
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
masa cząsteczkowa
antigen 47 kDa
reaktywność gatunkowa
rat, mouse, human
stężenie
~1 mg/mL
metody
ELISA: 1:20000
western blot: 1:500-1:1000
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
phosphorylation (pSer396)
informacje o genach
human ... IRF3(3661)
Opis ogólny
IRF3 (interferon regulatory factor 3) is a transcription factor belonging to the IRF family and is involved in the innate immunity response against viruses and bacteria. The gene encoding IRF3 is localized on human chromosome 19q13.33.
Immunogen
The antiserum was produced against synthesized peptide derived from human IRF-3 around the phosphorylation site of Ser396.
Immunogen Range: 362-411
Immunogen Range: 362-411
Zastosowanie
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Działania biochem./fizjol.
Activated IRF3 (interferon regulatory factor 3) influences the expression of type I interferons via the toll-like receptor (TLR3/4)-mediated signaling pathway. IRF3 can suppress glioma invasion, proliferation and migration. Studies have suggested that IRF3 may have characteristics of tumor suppression.
Cechy i korzyści
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Postać fizyczna
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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polecane
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Interferon regulatory factor 3 alters glioma inflammatory and invasive properties
Leonid Tarassishin
Journal of Neuro-Oncology, 113 (2013)
Genetic susceptibility in cervical cancer: From bench to bedside
Afsane Bahrami
Journal of Cellular Physiology (2017)
Interferon regulatory factor 3 in adaptive immune responses.-Laure Ysebrant de Lendonck
Laure Ysebrant de Lendonck
Cellular and Molecular Life Sciences (2014)
Joyshree Karmakar et al.
Frontiers in immunology, 12, 626110-626110 (2021-03-26)
TLR4 activates two distinct signaling pathways involving adaptors MyD88 and TRIF to produce proinflammatory cytokines and type-I interferon respectively. How Leishmania donovani suppresses these pathways is not well studied. We earlier reported, TLR4 is hypersialylated due to reduced membrane-bound neuraminidase
Gina Córdoba-David et al.
Frontiers in pharmacology, 13, 987979-987979 (2022-11-18)
The type I interferon (TI-IFN) pathway regulates innate immunity, inflammation, and apoptosis during infection. However, the contribution of the TI-IFN pathway or upstream signaling pathways to tubular injury in kidney disease is poorly understood. Upon observing evidence of activation of
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