L8912

L-Leucine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

• Synonim(y): (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid
• Wzór liniowy: (CH₃)₂CHCH₂CH(NH₂)CO₂H
• Numer CAS: 61-90-5
• Masa cząsteczkowa: 131.17
• Beilstein: 1721722
• Numer WE: 200-522-0
• Numer MDL: MFCD00002617
• Kod UNSPSC: 12352209
• eCl@ss: 32160406
• Identyfikator substancji w PubChem: 24896510
• NACRES: NA.26

Właściwości

• Nazwa produktu: L-Leucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
• pochodzenie biologiczne: non-animal source
• Poziom jakości: 300
• agency: USP/NF; meets EP testing specifications; meets JP testing specifications; meets USP testing specifications
• Próba: 98.5-101.0%
• Formularz: powder
• aktywność optyczna: [α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl; [α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl
• jakość: meets EP, JP, USP testing specifications
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: endotoxin, tested
• kolor: white
• mp: >300 °C (lit.)
• rozpuszczalność: 1 M HCl: 50 mg/mL
• ślady kationów: As: ≤1 ppm; Fe: ≤10 ppm; NH₄⁺: <0.02%; heavy metals: ≤10 ppm
• Zastosowanie: peptide synthesis; pharmaceutical (small molecule)
• grupa funkcyjna: amine; carboxylic acid
• temp. przechowywania: room temp
• ciąg SMILES: CC(C)C[C@H](N)C(O)=O
• InChI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
• Klucz InChI: ROHFNLRQFUQHCH-YFKPBYRVSA-N

Opis

Opis ogólny

Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins.[1]

Zastosowanie

L-Leucine has been used:

• as a hypertrophic agent to monitor its effects on myotubes.[2]
• as a component of PMG media for culturing yeast.[3]
• in myotube protein synthesis analysis in skeletal muscle cells.[4]
• to study its effects on hepatic lipid metabolism.[5]

Działania biochem./fizjol.

Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue.[6] Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis.[1]

Inne uwagi

For additional information on our range of Biochemicals, please complete this form.

The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)