I7018

3-Isobutyl-1-methylxanthine

≥99%, BioUltra

• Synonim(y): 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX
• Wzór empiryczny (zapis Hilla): C₁₀H₁₄N₄O₂
• Numer CAS: 28822-58-4
• Masa cząsteczkowa: 222.24
• Beilstein: 247859
• Numer WE: 249-259-3
• Numer MDL: MFCD00005584
• Kod UNSPSC: 12352202
• Identyfikator substancji w PubChem: 24896107
• NACRES: NA.77

Właściwości

• linia produktu: BioUltra
• Poziom jakości: 200
• Próba: ≥99%
• zanieczyszczenia: <0.005% Phosphorus (P)
• pozostałość po prażeniu: <0.1%
• mp: 200-201 °C (lit.)
• rozpuszczalność: DMSO: soluble 1 M (with gentle warming)
• ślady anionów: sulfate (SO₄^2-): <0.05%
• ślady kationów: Al: <0.0005%; Ca: <0.005%; Cu: <0.0005%; Fe: <0.005%; K: <0.05%; Mg: <0.005%; NH₄⁺: <0.05%; Na: <0.005%; Pb: <0.001%; Zn: <0.0005%
• temp. przechowywania: −20°C
• ciąg SMILES: CC(C)CN1C(=O)N(C)C(=O)c2[nH]cnc12
• InChI: 1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
• Klucz InChI: APIXJSLKIYYUKG-UHFFFAOYSA-N
• informacje o genach: rat ... Adora1(29290) , Adora2a(25369)

Opis

Zastosowanie

3-Isobutyl-1-methylxanthine, an inhibitor of adenosine 3′,5′-cyclic monophosphate phosphodiesterase (cAMP PDE), has been used:

• for adipogenic differentiation[1]
• in tissue culture[2]
• 3T3-L1 preadipocyte differentiation([3]

Działania biochem./fizjol.

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC₅₀: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

Cechy i korzyści

• Trace element testing by ICP
• ICP testing for trace sulfur (as sulfate) and phosphorus (as phosphate) content
• Ion chromatography testing for trace ammonium content

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Faceshields, Gloves