This material should be stored refrigerated temperature at 2 - 8 °C. The product is assigned a retest date of approximately 2 years from the date of Quality release. The quality of this item cannot be quatanteed if stored outside of the recommended conditions for extended periods. Please see the link below to review the lot specific Certificate of Analysis to determine retest date:
https://www.sigmaaldrich.com/product/sigma/h8502#product-documentation
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H8502
Dopamine hydrochloride
≥98% (TLC), powder, neurotransmitter
Synonim(y):
2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride, 3,4-Dihydroxyphenethylamine hydrochloride, 3-Hydroxytyramine hydrochloride, 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride
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5 G
219,00 zł
10 G
385,00 zł
25 G
670,00 zł
100 G
2490,00 zł
219,00 zł
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5 G
219,00 zł
10 G
385,00 zł
25 G
670,00 zł
100 G
2490,00 zł
About This Item
Wzór liniowy:
(HO)2C6H3CH2CH2NH2·HCl
Numer CAS:
Masa cząsteczkowa:
189.64
Beilstein:
3656720
Numer WE:
Numer MDL:
Kod UNSPSC:
12352116
Identyfikator substancji w PubChem:
NACRES:
NA.77
219,00 zł
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Polecane produkty
Nazwa produktu
Dopamine hydrochloride,
Formularz
powder
Poziom jakości
kolor
light tan
mp
248-250 °C (lit.)
rozpuszczalność
alcohol: 20 mg/mL
H2O: soluble
temp. przechowywania
2-8°C
ciąg SMILES
Cl[H].NCCc1ccc(O)c(O)c1
InChI
1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
Klucz InChI
CTENFNNZBMHDDG-UHFFFAOYSA-N
informacje o genach
human ... ADRB1(153)
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Opis ogólny
Dopamine (DA) works as a neurotransmitter in the central nervous system.[1] It is a catecholamine made from the amino acid L-tyrosine. It also works as a hormone in the vesicles of the adrenal medulla, thereby controlling heart beat rate and blood pressure. The Absence of DA-containing neurons is associated with Parkinson’s disease.[2]Dopamine is produced and released by the dopaminergic neurons in the substantia nigra that is in the central nervous system.[3] It is involved in several activities such as movement, behaviour, learning, reward, punishment, dreaming, working, memory, mood, sleep, attention, and inhibition of prolactin production. Dopamine also acts as a precursor in the synthesis of catecholamines like epinephrine and norepinephrine.[4] Increased levels of dopamine via the tuberoinfundibular pathway are associated with Schizophrenia, hallucinations, euphoria, and psychosis.[4] A deficiency of dopamine and norepinephrine indicates the neurochemical basis for attention-deficit hyperactivity disorder (ADHD), a pediatric disorder.[5]
Zastosowanie
Dopamine hydrochloride has been used:
- to study dopamine-mediated transient modulation of the physiological responses in white leg shrimp, Litopenaeus vannamei.[6]
- to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.[7]
- to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an ‘in vitro’ model of parkinsonian Huntington′s Disease.[8]
- as a substrate of the prophenoloxidase (PPO) cascade reaction in the anti-microbial assay targeting methicillin-resistant staphylococcus aureus (MRSA) in the biofilm phase.[9]
- added exogenously to the culture medium to study its effect on H. contortus female worms.[10]
Cechy i korzyści
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Przestroga
Light sensitive
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Skin Sens. 1
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
dust mask type N95 (US), Eyeshields, Gloves
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Klienci oglądali również te produkty
Dopamine induces transient modulation of the physiological responses of whiteleg shrimp, Litopenaeus vannamei.
Chiu H-T et al.
Aquaculture (Amsterdam, Netherlands), 251, 558-566 (2006)
Natalia Del Campo et al.
Biological psychiatry, 69(12), e145-e157 (2011-05-10)
Through neuromodulatory influences over fronto-striato-cerebellar circuits, dopamine and noradrenaline play important roles in high-level executive functions often reported to be impaired in attention-deficit/hyperactivity disorder (ADHD). Medications used in the treatment of ADHD (including methylphenidate, dextroamphetamine and atomoxetine) act to increase
Flow injection with inhibited chemiluminescence method for the determination of dopamine hydrochloride.
Shuhao WANG et al.
Analytical Sciences, 20, 315-317 (2004)
Y Luo et al.
The Journal of biological chemistry, 273(6), 3756-3764 (1998-03-07)
Dopamine (DA) is a neurotransmitter, but it also exerts a neurotoxic effect under certain pathological conditions, including age-related neurodegeneration such as Parkinson's disease. By using both the 293 cell line and primary neonatal rat postmitotic striatal neuron cultures, we show
Rafael Franco et al.
Biomedicines, 9(2) (2021-01-28)
Dopamine is derived from an amino acid, phenylalanine, which must be obtained through the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher executive action, acts through five types of G-protein-coupled receptors. Dopamine has been studied
Produkty
DISCOVER Bioactive Small Molecules for Neuroscience
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How long can it be stored? I found two in our lab, but one at room temperature for years and another one in 10 oC fridge.
1 answer-
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Upon dissolving the H8502 powder, the solution turned dark purple/black. What could be the cause of this discoloration? Can the product still be considered suitable for use?
Upon dissolving the H8502 powder, the solution turned dark purple/black. What could be the cause of this discoloration? Can the product still be considered suitable for use?
1 answer-
Regarding the solubility of product H8502, it can be dissolved in alcohol at a concentration of 20 mg/mL or in water (H2O) at 100 mg/mL. It is recommended that solutions be prepared fresh and not stored for long-term use. Preparing aliquots for storage at -20°C or keeping the product in solution at 4-8°C is not advised.
Dopamine, the active component, is sensitive to light and the free base form is particularly prone to oxidation. Solutions with a pH range of 5.4 to 6.8 have been reported to remain stable for a maximum of 48 hours at 25°C, beyond which the solution may darken and become unusable.
Dopamine solutions should not be mixed with alkalis, iron salts, or oxidizing agents, and are known to be incompatible with certain antibiotics, including amphotericin, ampicillin, gentamicin sulfate, and benzylpenicillin.
In the literature, you can find some articles where the stability of this compound is indicated. For example: https://www.ncbi.nlm.nih.gov/pubmed/14651669
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Is this product analytical standard that can be used in LCMSMS to quantify the amount of Dopamine?
1 answer-
Unfortunately, this product is not tested as an analytical standard for use in LCMSMS.
Helpful?
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Can it be stored at -20C
1 answer-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
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