H17001
Wnt3A, human
recombinant, expressed in HEK 293 cells human
Synonim(y):
Wnt, Wnt-3A
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About This Item
Kod UNSPSC:
12352202
NACRES:
NA.77
Polecane produkty
rekombinowane
expressed in HEK 293 cells human
Próba
>90% (SDS-PAGE)
Postać
powder
siła działania
≤20 ng/mL EC50
masa cząsteczkowa
38-42 kDa
zanieczyszczenia
<1 EU/μg endotoxin
temp. przechowywania
−20°C
Opis ogólny
WNT3A (Wnt family member 3A) gene is mapped to human chromosome 1q42.13. Wnt3A gene is a member of the Wnt gene family that consists of structurally linked genes that encode secreted signaling proteins.
Działania biochem./fizjol.
WNT3A (Wnt family member 3A) functions mainly to induce canonical Wnt signaling pathway. Wnt signaling pathway is essential for gastrulation, organogenesis, tissue development, homeostasis and regeneration. Congenital defects, oncogenic transformation and many more disorders results due to abnormal Wnt signaling pathway. During the differentiation of human neuronal progenitor cells, WNT3A (Wnt family member 3A) activates calmodulin-dependent kinase II and increases free calcium in the cytosol via Wnt/Ca2+ signaling pathway. WNT3A is an oncogene and is upregulated in many types of cancer. It serves as a prognostic marker in diagnosing hepatocellular carcinoma. It also promotes metastasis of malignant tumors, including gastric cancer, colorectal cancer, non-small cell lung cancer and breast cancer.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution of 1X PBS pH 7.4 + 500mM NaCl + 1% CHAPS.
Rekonstytucja
It is recommended to reconstitute the protein to ≤100μg/mL in sterile 1X PBS containing 0.1% endotoxin-free HSA.
Przechowywanie i stabilność
Upon reconstitution, the cytokine can be stored at 4°C for short term or at -20°C to -80°C in aliquots for long term. Avoid repeated freeze-thaw cycles.
Komentarz do analizy
The activity was determined by dose dependent Alkaline Phosphatase production in MC3T3 E1 mouse preosteoblast cells and stabilization of beta catenin in mouse L929 cells.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
Huggins IJ, et al.
Nature Communications, 8(1), 1034-1034 (2017)
The Wnt inhibitor LGK-974 enhances radiosensitivity of HepG2 cells by modulating Nrf2 signaling
Tian D, et al.
International Journal of Oncology, 51(2), 545-554 (2017)
Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis
Lu C, et al.
International Journal of Oncology, 51(4), 1135-1145 (2017)
Non-canonical pathway induced by Wnt3a regulates ?-catenin via Pyk2 in differentiating human neural progenitor cells.
Narendra Talabattula VA
Biochemical and Biophysical Research Communications, 491(1), 40-46 (2017)
Produkty
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